Publications [#237026] of John H. Reif

Journal articles or Book chapters PUBLISHED

1. Majumder, U; Sahu, S; LaBean, TH; Reif, JH, Design and simulation of self-repairing DNA lattices, Lecture Notes in Computer Science Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics, vol. 4287 LNCS (December, 2006), pp. 195-214, Springer Berlin Heidelberg, ISSN 0302-9743 [doi]
   (last updated on 2026/01/15)

   Abstract:
   Self-repair is essential to all living systems, providing the ability to remain functional in spite of gradual damage. In the context of self-assembly of self-repairing synthetic biomolecular systems, recently Winfree developed a method for transforming a set of DNA tiles into its self-healing counterpart at the cost of increasing the lattice area by a factor of 25. The overall focus of this paper, however, is to develop compact designs for self-repairing tiling assemblies with reasonable constraints on crystal growth. Specifically, we use a special class of DNA tiling designs called reversible tiling which when carefully designed can provide inherent self-repairing capabilities to patterned DNA lattices. We further note that we can transform any irreversible computational DNA tile set to its reversible counterpart and hence improve the self-repairability of the computational lattice. But doing the transform with an optimal number of tiles, is still an open question. © 2006 Springer-Verlag.