Publications [#237054] of John H. Reif

Journal articles or Book chapters PUBLISHED

1. Majumder, U; Rangnekar, A; Gothelf, KV; Reif, JH; LaBean, TH, Design and construction of double-decker tile as a route to three-dimensional periodic assembly of DNA., Journal of the American Chemical Society, vol. 133 no. 11 (March, 2011), pp. 3843-3845 [21355587], [doi]
   (last updated on 2026/01/14)

   Abstract:
   DNA is a useful material for nanoscale construction. Due to highly specific Watson-Crick base pairing, the DNA sequences can be designed to form small tiles or origami. Adjacent helices in such nanostructures are connected via Holliday junction-like crossovers. DNA tiles can have sticky ends which can then be programmed to form large one-dimensional and two-dimensional periodic lattices. Recently, a three-dimensional DNA lattice has also been constructed. Here we report the design and construction of a novel DNA cross tile, called the double-decker tile. Its arms are symmetric and have four double helices each. Using its sticky ends, large two-dimensional square lattices have been constructed which are on the order of tens of micrometers. Furthermore, it is proposed that the sticky ends of the double-decker tile can be programmed to form a three-dimensional periodic lattice with large cavities that could be used as a scaffold for precise positioning of molecules in space.