Publications [#228458] of Steven B. Haase

Papers Published

1. Simmons Kovacs, LA; Mayhew, MB; Orlando, DA; Jin, Y; Li, Q; Huang, C; Reed, SI; Mukherjee, S; Haase, SB, Cyclin-dependent kinases are regulators and effectors of oscillations driven by a transcription factor network., Molecular cell, vol. 45 no. 5 (March, 2012), pp. 669-679, Elsevier BV, ISSN 1097-2765 [22306294], [doi]
   (last updated on 2026/01/14)

   Abstract:
   During embryonic cell cycles, B-cyclin-CDKs function as the core component of an autonomous oscillator. Current models for the cell-cycle oscillator in nonembryonic cells are slightly more complex, incorporating multiple G1, S phase, and mitotic cyclin-CDK complexes. However, periodic events persist in yeast cells lacking all S phase and mitotic B-cyclin genes, challenging the assertion that cyclin-CDK complexes are essential for oscillations. These and other results led to the proposal that a network of sequentially activated transcription factors functions as an underlying cell-cycle oscillator. Here we examine the individual contributions of a transcription factor network and cyclin-CDKs to the maintenance of cell-cycle oscillations. Our findings suggest that while cyclin-CDKs are not required for oscillations, they do contribute to oscillation robustness. A model emerges in which cyclin expression (thereby, CDK activity) is entrained to an autonomous transcriptional oscillator. CDKs then modulate oscillator function and serve as effectors of the oscillator.

   Keywords:
   CDC2 Protein Kinase • Cell Cycle • Cyclin-Dependent Kinases • Gene Expression Regulation, Fungal* • Transcription Factors • Yeasts • cytology* • enzymology • genetics • genetics* • metabolism • physiology • physiology*