Publications [#262674] of Tuan Vo-Dinh

Papers Published

1. Scaffidi, JP; Gregas, MK; Seewaldt, V; Dinh, TV, Fiber optic SERS-based plasmonics nanobiosensing in single living cells, Proceedings of SPIE the International Society for Optical Engineering, vol. 7312 (September, 2009), SPIE, ISSN 0277-786X [doi]
   (last updated on 2026/01/19)

   Abstract:
   We describe the development of small molecule-sensitive plasmonics-active fiber-optic nanoprobes suitable for intracellular bioanalysis in single living human cells using surface-enhanced Raman scattering (SERS) detection. The practical utility of SERS-based fiber-optic nanoprobes is illustrated by measurements of intracellular pH in HMEC-15/hTERT immortalized "normal" human mammary epithelial cells and PC-3 human prostate cancer cells. The results indicate that fiber-optic nanoprobe insertion and interrogation provide a sensitive and selective means to monitor biologically-relevant small molecules at the single cell level. ©2009 SPIE.