Publications [#262737] of Tuan Vo-Dinh

Papers Published

1. Alarie, JP; Vo-Dinh, T, Antibody-based submicron biosensor for Benzo[a]pyrene DNA adduct, Polycyclic Aromatic Compounds, vol. 8 no. 1 (January, 1996), pp. 45-52, Informa UK Limited [doi]
   (last updated on 2026/01/20)

   Abstract:
   Fiberoptic-based sensors have been developed for monitoring human exposure and health effects associated with polycyclic aromatic compounds such as benzo[a]pyrene. These sensors take advantage of the physical properties of optical fibers including their relatively small size, remote sensing capabilities, and their inertness to electrical interferences. The recent development of submicron-sized optical fibers provides an opportunity to further reduce the size of fiberoptic-based sensors for application in submicron environments. This paper describes the development of an antibody based submicron fiber biosensor. The antibody-based biosensor is more selective and sensitive than a nonantibody sensor and has an absolute detection limit of ≈300 zeptomoles (10^-21 moles) for benzo pyrene tetrol, a product of the benzo[a]pyrene DNA adduct. This submicron-size biosensor could provide a useful tool for measurements of toxic chemicals and related metabolites in sub cellularsize environments.