Publications [#262784] of Tuan Vo-Dinh

Papers Published

1. Scaffidi, JP; Gregas, MK; Seewaldt, V; Vo-Dinh, T, SERS-based plasmonic nanobiosensing in single living cells., Analytical and bioanalytical chemistry, vol. 393 no. 4 (February, 2009), pp. 1135-1141, ISSN 1618-2642 [19066865], [doi]
   (last updated on 2026/01/20)

   Abstract:
   In this paper, we describe the development and application of a pH-sensitive plasmonics-active fiber-optic nanoprobe suitable for intracellular bioanalysis in single living human cells using surface-enhanced Raman scattering (SERS) detection. The effectiveness and usefulness of SERS-based fiber-optic nanoprobes are illustrated by measurements of intracellular pH in HMEC-15/hTERT immortalized "normal" human mammary epithelial cells and PC-3 human prostate cancer cells. The results indicate that fiber-optic nanoprobe insertion and interrogation provide a sensitive and selective means to monitor cellular microenvironments at the single cell level.