Publications [#359839] of Warren S. Warren

Journal Articles

1. Bae, J; Zhang, G; Park, H; Warren, WS; Wang, Q, ¹⁵N-Azides as practical and effective tags for developing long-lived hyperpolarized agents., Chemical science, vol. 12 no. 42 (November, 2021), pp. 14309-14315 [doi]
   (last updated on 2026/01/14)

   Abstract:
   Azide moieties, unique linear species containing three nitrogen atoms, represent an attractive class of molecular tag for hyperpolarized magnetic resonance imaging (HP-MRI). Here we demonstrate (¹⁵N)₃-azide-containing molecules exhibit long-lasting hyperpolarization lifetimes up to 9.8 min at 1 T with remarkably high polarization levels up to 11.6% in water, thus establishing (¹⁵N)₃-azide as a powerful spin storage for hyperpolarization. A single (¹⁵N)-labeled azide has also been examined as an effective alternative tag with long-lived hyperpolarization. A variety of biologically important molecules are studied in this work, including choline, glucose, amino acid, and drug derivatives, demonstrating great potential of ¹⁵N-labeled azides as universal hyperpolarized tags for nuclear magnetic resonance imaging applications.