Publications [#65207] of Michael R. Zalutsky

Papers Published

1. Zalutsky, Michael R. and Narula, Acharan S., ASTATINATION OF PROTEINS USING AN N-SUCCINIMIDYL TRI-n-BUTYLSTANNYL BENZOATE INTERMEDIATE., Applied Radiation and Isotopes, vol. 39 no. 3 (1988), pp. 227 - 232 [0883-2889(88)90176-1]
   (last updated on 2007/04/15)

   Abstract:
   A method is described for labeling proteins with 7. 2 h half-life **2**1**1At. The alpha particle-emitting nuclide was coupled to goat IgG using an N-succinimidyl 3-(tri-n-butylstannyl) benzoate intermediate. The reaction and purification sequence requires about 2 h to produce **2**1**1At-labeled IgG in 25-40% radiochemical yield. Comparative blood clearance measurements in mice suggest that the **2**1**1At-labeled IgG conjugate is stable in vivo.

   Keywords:
   ASTATINE - Isotopes;BIOMEDICAL EQUIPMENT - Radionuclides;RADIOACTIVE MATERIALS - Tracers;BIOLOGICAL MATERIALS - Blood;