Publications [#65213] of Michael R. Zalutsky

Papers Published

1. Larsen, R.H. and Weiland, B.W. and Zalutsky, M.R., Evaluation of an internal cyclotron target for the production of ²¹¹At via the ²⁰⁹Bi(α,2n)²¹¹At reaction, Appl. Radiat. Isot. (UK), vol. 47 no. 2 (1996), pp. 135 - 43 [0969-8043(95)00285-5]
   (last updated on 2007/04/15)

   Abstract:
   Astatine-211 is a 7.2h half-life α-emitting radionuclide which has shown great promise for targeted radiotherapy. It is generally produced by cyclotron bombardment of bismuth metal targets with 28 MeV α-particles via the ²⁰⁹Bi(α,2n)²¹¹At reaction. In order to provide ²¹¹At activity levels anticipated for clinical investigations, an internal target system has been designed and evaluated. The system has a grazing-angle configuration and leading- and trailing-edge monitors. Both aluminum and copper target backings were evaluated. With approx. 28 MeV α-particles, the ²¹¹At production efficiency was 41±7 MBq/μA·h, compared with 10.6±1.2 MBq/μA h for an external target. Radionuclidic purity of ²¹¹At was high with no evidence of ²¹⁰At

   Keywords:
   alpha particle-nucleus reactions;astatine;bismuth;neutron production;nuclear bombardment targets;nuclei with mass number 190 to 219;radioisotopes;