Publications [#65253] of Michael R. Zalutsky

Papers Published

1. McLendon, R.E. and Archer, G.E. and Garg, P.K. and Bigner, D.D. and Zalutsky, M.R., Radiotoxicity of systemically administered [²¹¹At]astatide in B6C3F₁ and BALB/c (NU/NU) mice: a long-term survival study with histologic analysis, Int. J. Radiat. Oncol. Biol. Phys. (USA), vol. 35 no. 1 (1996), pp. 69 - 80 [S0360-3016(96)85013-9]
   (last updated on 2007/04/15)

   Abstract:
   The present study undertook to establish the dose (LD) of systemically administered (via tail vein) sodium [²¹¹At]astatide that would kill 10% (LD₁₀) of exposed animals in two mouse models and to evaluate the resulting histologic lesions. Three dose escalation experiments were carried out using groups of 10 3- to 4- week-old, 20±2 g B6C3F₁ mice, and one dose escalation experiment was carried out with groups of 10 4- to 6-week-old, 22±2 g BALB/c (nu/nu) mice. All animals were weighed daily and checked twice daily for general health; autopsies were performed within 12 h of death. The LD₁₀ (95% confidence interval) level of free [²¹¹At]astatide at 360 days was 15.1 μCi (5.2-19.1 μCi) in B6C3F₁ mice and was associated with a 37.8% weight difference from saline controls (p<0.001). In the BALB/c (nu/nu) mice, the LD₁₀ at 360 days was 7.7 μCi (0-14.2 μCi), while a dose of 10 μCi (0.42 μCi g^-1) was associated with a 9.44% weight difference vs. saline controls (p<0.05). Exclusive of the well-known effects on thyroid, [²¹¹At]astatide activity levels were associated with severe bone marrow depression, testicular atrophy, focal alopecia, and nuclear atypia of the epidermoid mucosa of the forestomach in the B6C3F₁ mice; at activity levels approximating LD₁₀ at 360 days, mild changes in the heart, liver, stomach, and spleen were observed. For BALB/c (nu/nu) mice, administration of 10 μCi was associated at autopsy with mild histologic lesions in the heart, stomach, liver, and spleen. These studies provide a basis for the design of further investigations of [²¹¹At]-labeled compounds as therapeutic agents

   Keywords:
   alpha-particle effects;astatine;biological effects of ionising particles;radioisotopes;