Publications [#260980] of Ashutosh Chilkoti

Papers Published

1. Meyer, DE; Chilkoti, A, Quantification of the effects of chain length and concentration on the thermal behavior of elastin-like polypeptides., Biomacromolecules, vol. 5 no. 3 (May, 2004), pp. 846-851, ISSN 1525-7797 [15132671], [doi]
   (last updated on 2026/01/15)

   Abstract:
   At a specific temperature, elastin-like polypeptides (ELPs) undergo a sharp solubility transition that can be exploited in a variety of applications in biotechnology and medicine. The temperature of the transition varies with ELP sequence, molecular weight, and concentration. We present a single equation of three parameters that quantitatively predicts the transition temperature as a function of ELP length and concentration for an ELP of a fixed composition. This model should be useful both for the design of new ELP sequences that exhibit a desired transition temperature and for the selection of variables to trigger the phase transition of an ELP for a given application.

   Keywords:
   Proteins;Biotechnology;Medicine;Molecular weight;Superconducting transition temperature;Phase transitions;