Publications [#168961] of Mark W. Dewhirst

Papers Published

1. AC Kasper, EJ Moon, X Hu, Y Park, CM Wooten, H Kim, W Yang, MW Dewhirst, J Hong, Analysis of HIF-1 inhibition by manassantin A and analogues with modified tetrahydrofuran configurations., Bioorganic & medicinal chemistry letters, England, vol. 19 no. 14 (July, 2009), pp. 3783-6, ISSN 1464-3405
   (last updated on 2009/12/31)

   Abstract:
   We have shown that manassantin A downregulated the HIF-1alpha expression and inhibited the secretion of VEGF. We have also demonstrated that the 2,3-cis-3,4-trans-4,5-cis-configuration of the tetrahydrofuran is critical to the HIF-1 inhibition of manassantin A.

   Keywords:
   Animals • Cell Line • Furans • Hypoxia-Inducible Factor 1 • Lignans • Mice • Vascular Endothelial Growth Factor A • antagonists & inhibitors* • chemical synthesis • chemistry* • metabolism • pharmacology • secretion