Publications [#169012] of Mark W. Dewhirst

Papers Published

1. BJ Moeller, MW Dewhirst, HIF-1 and tumour radiosensitivity., British journal of cancer, England, vol. 95 no. 1 (July, 2006), pp. 1-5, ISSN 0007-0920
   (last updated on 2009/12/31)

   Abstract:
   Hypoxia-inducible factor-1 (HIF-1) plays important roles in regulating radiosensitivity, making it a potentially promising target for tumour radiosensitisation. Here, we discuss the rationale for, and the potential pitfalls of, combining HIF-1 blockade with radiotherapy. In doing so, we describe clinical scenarios in which HIF-1 inhibition might optimise tumour radiosensitivity.

   Keywords:
   Cell Hypoxia • Gene Expression Regulation, Neoplastic • Humans • Hypoxia-Inducible Factor 1 • Neoplasms • Radiation Tolerance* • genetics • metabolism • pathology • physiology* • radiation effects • radiation effects* • radiotherapy*