Publications [#63183] of Mark W. Dewhirst

Papers Published

1. Sapozink, M.D. and Corry, P.M. and Kapp, D.S. and Myerson, R.J. and Dewhirst, M.W. and Emami, B. and Herman, T. and Prionas, S. and Ryan, T. and Samulski, T. and Sapareto, S. and Shrivastava, P. and Stauffer, P. and Waterman, F., RTOG quality assurance guidelines for clinical trials using hyperthermia for deep-seated malignancy, Int. J. Radiat. Oncol. Biol. Phys. (UK), vol. 20 no. 5 (1991), pp. 1109 - 15
   (last updated on 2007/04/14)

   Abstract:
   Quality assurance has been vague or lacking in many previous hyperthermia trials. Recent publications by the Hyperthermia Physics Center, the Center for Devices and Regulatory Health, and the Radiation Therapy Oncology Group have described general guidelines for quality assurance in equipment reliability and reproducibility, superficial applications, and microwave techniques. The present report details quality assurance factors that are believed to be important for hyperthermia of deep clinical sites, defined as extending at least 3 cm beyond the skin surface. The authors discuss patient and physician factors, as well as thermometric accuracy, assessment of specific absorption rates (SAR), assurance of adequate coverage of tumors by the energy deposition pattern of the treatment device, and recommended documentation of the location, quantity, and frequency of treatment, specifically oriented to deep hyperthermia. The recommendations are structured to facilitate compliance in multiinstitutional trials

   Keywords:
   biothermics;quality control;radiation therapy;