Publications [#279767] of Farshid Guilak

Papers Published

1. Liao, IC; Moutos, FT; Estes, BT; Zhao, X; Guilak, F, Composite three-dimensional woven scaffolds with interpenetrating network hydrogels to create functional synthetic articular cartilage, Advanced Functional Materials, vol. 23 no. 47 (December, 2013), pp. 5833-5839, ISSN 1616-301X [doi]
   (last updated on 2019/06/30)

   Abstract:
   The development of synthetic biomaterials that possess mechanical properties mimicking those of native tissues remains an important challenge to the field of materials. In particular, articular cartilage is a complex nonlinear, viscoelastic, and anisotropic material that exhibits a very low coefficient of friction, allowing it to withstand millions of cycles of joint loading over decades of wear. Here, a three-dimensionally woven fiber scaffold that is infiltrated with an interpenetrating network hydrogel can build a functional biomaterial that provides the load-bearing and tribological properties of native cartilage. An interpenetrating dual-network "tough-gel" consisting of alginate and polyacrylamide was infused into a porous three-dimensionally woven poly(ε-caprolactone) fiber scaffold, providing a versatile fiber-reinforced composite structure as a potential acellular or cell-based replacement for cartilage repair. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.