Publications [#317920] of Charmaine D. Royal

Essays, Articles, Chapters in Books

1. Sabeti, PC; Varilly, P; Fry, B; Lohmueller, J; Hostetter, E; Cotsapas, C; Xie, X; Byrne, EH; McCarroll, SA; Gaudet, R; Schaffner, SF; Lander, ES; International HapMap Consortium; Frazer, KA; Ballinger, DG; Cox, DR; Hinds, DA; Stuve, LL; Gibbs, RA; Belmont, JW; Boudreau, A; Hardenbol, P; Leal, SM; Pasternak, S; Wheeler, DA; Willis, TD; Yu, F; Yang, H; Zeng, C; Gao, Y; Hu, H; Hu, W; Li, C; Lin, W; Liu, S; Pan, H; Tang, X; Wang, J; Wang, W; Yu, J; Zhang, B; Zhang, Q; Zhao, H; Zhao, H; Zhou, J; Gabriel, SB; Barry, R; Blumenstiel, B; Camargo, A; Defelice, M; Faggart, M; Goyette, M; Gupta, S; Moore, J; Nguyen, H; Onofrio, RC; Parkin, M; Roy, J; Stahl, E; Winchester, E; Ziaugra, L; Altshuler, D; Shen, Y; Yao, Z; Huang, W; Chu, X; He, Y; Jin, L; Liu, Y; Shen, Y; Sun, W; Wang, H; Wang, Y; Wang, Y; Xiong, X; Xu, L; Waye, MMY; Tsui, SKW; Xue, H; Wong, JT-F; Galver, LM; Fan, J-B; Gunderson, K; Murray, SS; Oliphant, AR; Chee, MS; Montpetit, A; Chagnon, F; Ferretti, V; Leboeuf, M; Olivier, J-F; Phillips, MS; Roumy, S; Sallée, C; Verner, A; Hudson, TJ; Kwok, P-Y; Cai, D; Koboldt, DC; Miller, RD; Pawlikowska, L; Taillon-Miller, P; Xiao, M; Tsui, L-C; Mak, W; Song, YQ; Tam, PKH; Nakamura, Y; Kawaguchi, T; Kitamoto, T; Morizono, T; Nagashima, A; Ohnishi, Y; Sekine, A; Tanaka, T; Tsunoda, T; Deloukas, P; Bird, CP; Delgado, M; Dermitzakis, ET; Gwilliam, R; Hunt, S; Morrison, J; Powell, D; Stranger, BE; Whittaker, P; Bentley, DR; Daly, MJ; de Bakker, PIW; Barrett, J; Chretien, YR; Maller, J; McCarroll, S; Patterson, N; Pe'er, I; Price, A; Purcell, S; Richter, DJ; Sabeti, P; Saxena, R; Sham, PC; Stein, LD; Krishnan, L; Smith, AV; Tello-Ruiz, MK; Thorisson, GA; Chakravarti, A; Chen, PE; Cutler, DJ; Kashuk, CS; Lin, S; Abecasis, GR; Guan, W; Li, Y; Munro, HM; Qin, ZS; Thomas, DJ; McVean, G; Auton, A; Bottolo, L; Cardin, N; Eyheramendy, S; Freeman, C; Marchini, J; Myers, S; Spencer, C; Stephens, M; Donnelly, P; Cardon, LR; Clarke, G; Evans, DM; Morris, AP; Weir, BS; Johnson, TA; Mullikin, JC; Sherry, ST; Feolo, M; Skol, A; Zhang, H; Matsuda, I; Fukushima, Y; Macer, DR; Suda, E; Rotimi, CN; Adebamowo, CA; Ajayi, I; Aniagwu, T; Marshall, PA; Nkwodimmah, C; Royal, CDM; Leppert, MF; Dixon, M; Peiffer, A; Qiu, R; Kent, A; Kato, K; Niikawa, N; Adewole, IF; Knoppers, BM; Foster, MW; Clayton, EW; Watkin, J; Muzny, D; Nazareth, L; Sodergren, E; Weinstock, GM; Yakub, I; Birren, BW; Wilson, RK; Fulton, LL; Rogers, J; Burton, J; Carter, NP; Clee, CM; Griffiths, M; Jones, MC; McLay, K; Plumb, RW; Ross, MT; Sims, SK; Willey, DL; Chen, Z; Han, H; Kang, L; Godbout, M; Wallenburg, JC; L'Archevêque, P; Bellemare, G; Saeki, K; Wang, H; An, D; Fu, H; Li, Q; Wang, Z; Wang, R; Holden, AL; Brooks, LD; McEwen, JE; Guyer, MS; Wang, VO; Peterson, JL; Shi, M; Spiegel, J; Sung, LM; Zacharia, LF; Collins, FS; Kennedy, K; Jamieson, R; Stewart, J, Genome-wide detection and characterization of positive selection in human populations., Nature, vol. 449 no. 7164 (October, 2007), pp. 913-918 [doi]
   (last updated on 2026/01/20)

   Abstract:
   With the advent of dense maps of human genetic variation, it is now possible to detect positive natural selection across the human genome. Here we report an analysis of over 3 million polymorphisms from the International HapMap Project Phase 2 (HapMap2). We used 'long-range haplotype' methods, which were developed to identify alleles segregating in a population that have undergone recent selection, and we also developed new methods that are based on cross-population comparisons to discover alleles that have swept to near-fixation within a population. The analysis reveals more than 300 strong candidate regions. Focusing on the strongest 22 regions, we develop a heuristic for scrutinizing these regions to identify candidate targets of selection. In a complementary analysis, we identify 26 non-synonymous, coding, single nucleotide polymorphisms showing regional evidence of positive selection. Examination of these candidates highlights three cases in which two genes in a common biological process have apparently undergone positive selection in the same population:LARGE and DMD, both related to infection by the Lassa virus, in West Africa;SLC24A5 and SLC45A2, both involved in skin pigmentation, in Europe; and EDAR and EDA2R, both involved in development of hair follicles, in Asia.