Publications [#317925] of Charmaine D. Royal

Essays, Articles, Chapters in Books

1. Baffoe-Bonnie, AB; Kittles, RA; Gillanders, E; Ou, L; George, A; Robbins, C; Ahaghotu, C; Bennett, J; Boykin, W; Hoke, G; Mason, T; Pettaway, C; Vijayakumar, S; Weinrich, S; Jones, MP; Gildea, D; Riedesel, E; Albertus, J; Moses, T; Lockwood, E; Klaric, M; Faruque, M; Royal, C; Trent, JM; Berg, K; Collins, FS; Furbert-Harris, PM; Bailey-Wilson, JE; Dunston, GM; Powell, I; Carpten, JD, Genome-wide linkage of 77 families from the African American Hereditary Prostate Cancer study (AAHPC)., The Prostate, vol. 67 no. 1 (January, 2007), pp. 22-31 [doi]
   (last updated on 2026/01/21)

   Abstract:
   

   Background

   The African American Hereditary Prostate Cancer (AAHPC) Study was designed to recruit families with early-onset disease fulfilling criteria of >or=4 affected.

   Methods

   We present a approximately 10 cM genome-wide linkage (GWL) analysis on 77 families including 254 affected and 274 unaffected genotyped.

   Results

   Linkage analysis revealed three chromosomal regions with GENEHUNTER multipoint HLOD scores >or=1.3 for all 77 families at 11q22, 17p11, and Xq21. One family yielded genome-wide significant evidence of linkage (LOD = 3.5) to the 17p11 region with seven other families >or=2.3 in this region. Twenty-nine families with no-male-to-male (MM) transmission gave a peak HLOD of 1.62 (alpha = 0.33) at the Xq21 locus. Two novel peaks >or=0.91 for the 16 families with '>6 affected' occurred at 2p21 and 22q12.

   Conclusions

   These chromosomal regions in the genome warrant further follow-up based on the hypothesis of multiple susceptibility genes with modest effects, or several major genes segregating in small subsets of families.