Publications of Dewey G. McCafferty

Journal Articles

  1. Hatstat, AK; Quan, B; Bailey, MA; Fitzgerald, MC; Reinhart, MC; McCafferty, DG, "Chemoproteomic-enabled characterization of small GTPase Rab1a as a target of an N-arylbenzimidazole ligand's rescue of Parkinson's-associated cell toxicity.", RSC chemical biologyJanuary,, 2022, 3(1), 96-111 [doi] [abs].

  2. Dudiak, BM; Nguyen, TM; Needham, D; Outlaw, TC; McCafferty, DG, "Inhibition of the futalosine pathway for menaquinone biosynthesis suppresses Chlamydia trachomatis infection.", FEBS lettersDecember,, 2021, 595(24), 2995-3005 [doi] [abs].

  3. Hatstat, AK; Pupi, MD; Reinhart, MC; McCafferty, DG, "Small Molecule Improvement of Trafficking Defects in Models of Neurodegeneration.", ACS chemical neuroscienceNovember,, 2021, 12(21), 3972-3984 [doi] [abs].

  4. Stariha, LM; McCafferty, DG, "Discovery of the Class I Antimicrobial Lasso Peptide Arcumycin.", Chembiochem : a European journal of chemical biologyAugust,, 2021, 22(16), 2632-2640 [doi] [abs].

  5. Hatstat, AK; Ahrendt, HD; Foster, MW; Mayne, L; Moseley, MA; Englander, SW; McCafferty, DG, "Characterization of Small-Molecule-Induced Changes in Parkinson's-Related Trafficking via the Nedd4 Ubiquitin Signaling Cascade.", Cell Chem BiolJanuary,, 2021, 28(1), 14-25.e9 [doi] [abs].

  6. Hatstat, AK; Pupi, MD; McCafferty, DG, "Predicting PY motif-mediated protein-protein interactions in the Nedd4 family of ubiquitin ligases.", PloS oneJanuary,, 2021, 16(10), e0258315 [doi] [abs].

  7. Morgan, KT; Zheng, J; McCafferty, DG, "Discovery of Six Ramoplanin Family Gene Clusters and the Lipoglycodepsipeptide Chersinamycin*.", Chembiochem : a European journal of chemical biologyJanuary,, 2021, 22(1), 176-185 [doi] [abs].

  8. Hatstat, AK; McCafferty, DG, "Robust and facile purification of full-length, untagged human Nedd4 as a recombinant protein from Escherichia coli.", Protein expression and purificationSeptember,, 2020, 173, 105649 [doi] [abs].

  9. Dudiak, BM; Maksimchuk, KR; Bednar, MM; Podracky, CJ; Burg, JM; Nguyen, TM; Nwogbo, FO; Valdivia, RH; McCafferty, DG, "Insights into the Autoproteolytic Processing and Catalytic Mechanism of the Chlamydia trachomatis Virulence-Associated Protease CPAF.", BiochemistryAugust,, 2019, 58(33), 3527-3536 [doi] [abs].

  10. Biniossek, ML; Niemer, M; Maksimchuk, K; Mayer, B; Fuchs, J; Huesgen, PF; McCafferty, DG; Turk, B; Fritz, G; Mayer, J; Haecker, G; Mach, L; Schilling, O, "Identification of Protease Specificity by Combining Proteome-Derived Peptide Libraries and Quantitative Proteomics.", Molecular & cellular proteomics : MCPJuly,, 2016, 15(7), 2515-2524 [doi] [abs].

  11. Burg, JM; Gonzalez, JJ; Maksimchuk, KR; McCafferty, DG, "Lysine-Specific Demethylase 1A (KDM1A/LSD1): Product Recognition and Kinetic Analysis of Full-Length Histones.", BiochemistryMarch,, 2016, 55(11), 1652-1662 [doi] [abs].

  12. Maksimchuk, KR; Alser, KA; Mou, R; Valdivia, RH; McCafferty, DG, "The Chlamydia trachomatis Protease CPAF Contains a Cryptic PDZ-Like Domain with Similarity to Human Cell Polarity and Tight Junction PDZ-Containing Proteins.", PLoS One, 2016, 11(2), e0147233 [doi] [abs].

  13. Burg, JM; Makhoul, AT; Pemble, CW; Link, JE; Heller, FJ; McCafferty, DG, "A rationally-designed chimeric KDM1A/KDM1B histone demethylase tower domain deletion mutant retaining enzymatic activity.", FEBS lettersAugust,, 2015, 589(18), 2340-2346 [doi] [abs].

  14. Burg, JM; Link, JE; Morgan, BS; Heller, FJ; Hargrove, AE; McCafferty, DG, "KDM1 class flavin-dependent protein lysine demethylases.", BiopolymersJuly,, 2015, 104(4), 213-246 [doi] [abs].

  15. Snavely, EA; Kokes, M; Dunn, JD; Saka, HA; Nguyen, BD; Bastidas, RJ; McCafferty, DG; Valdivia, RH, "Reassessing the role of the secreted protease CPAF in Chlamydia trachomatis infection through genetic approaches.", Pathog DisAugust,, 2014, 71(3), 336-351 [doi] [abs].

  16. McCafferty, DG; Melvin, JA, "Sortases"August,, 2013, 2, 2459-2465, Elsevier [doi].

  17. Qi, Y; Amiram, M; Gao, W; McCafferty, DG; Chilkoti, A, "Sortase-catalyzed initiator attachment enables high yield growth of a stealth polymer from the C terminus of a protein.", Macromolecular rapid communicationsAugust,, 2013, 34(15), 1256-1260 [23836349], [doi] [abs].

  18. Bellucci, JJ; Amiram, M; Bhattacharyya, J; McCafferty, D; Chilkoti, A, "Three-in-one chromatography-free purification, tag removal, and site-specific modification of recombinant fusion proteins using sortase A and elastin-like polypeptides.", Angewandte Chemie (International ed. in English)March,, 2013, 52(13), 3703-3708 [23424160], [doi].

  19. Folk, DS; Torosian, JC; Hwang, S; McCafferty, DG; Franz, KJ, "Monitoring β-secretase activity in living cells with a membrane-anchored FRET probe.", Angewandte Chemie (International ed. in English)October,, 2012, 51(43), 10795-10799 [23023944], [doi].

  20. Pollock, JA; Larrea, MD; Jasper, JS; McDonnell, DP; McCafferty, DG, "Lysine-specific histone demethylase 1 inhibitors control breast cancer proliferation in ERα-dependent and -independent manners.", ACS Chem BiolJuly,, 2012, 7(7), 1221-1231 [22533360], [doi] [abs].

  21. Weinberg, DR; Gagliardi, CJ; Hull, JF; Murphy, CF; Kent, CA; Westlake, BC; Paul, A; Ess, DH; McCafferty, DG; Meyer, TJ, "Proton-coupled electron transfer.", Chemical reviewsJuly,, 2012, 112(7), 4016-4093 [doi] [abs].

  22. Hoertz, AJ; Hamburger, JB; Gooden, DM; Bednar, MM; McCafferty, DG, "Studies on the biosynthesis of the lipodepsipeptide antibiotic Ramoplanin A2.", Bioorganic & medicinal chemistryJanuary,, 2012, 20(2), 859-865 [22222159], [doi] [abs].

  23. Bednar, MM; Jorgensen, I; Valdivia, RH; McCafferty, DG, "Chlamydia protease-like activity factor (CPAF): characterization of proteolysis activity in vitro and development of a nanomolar affinity CPAF zymogen-derived inhibitor.", BiochemistrySeptember,, 2011, 50(35), 7441-7443 [21830778], [doi] [abs].

  24. Melvin, JA; Murphy, CF; Dubois, LG; Thompson, JW; Moseley, MA; McCafferty, DG, "Staphylococcus aureus sortase A contributes to the Trojan horse mechanism of immune defense evasion with its intrinsic resistance to Cys184 oxidation.", BiochemistrySeptember,, 2011, 50(35), 7591-7599 [21812416], [doi] [abs].

  25. Jorgensen, I; Bednar, MM; Amin, V; Davis, BK; Ting, JPY; McCafferty, DG; Valdivia, RH, "The Chlamydia protease CPAF regulates host and bacterial proteins to maintain pathogen vacuole integrity and promote virulence.", Cell Host MicrobeJuly,, 2011, 10(1), 21-32 [21767809], [doi] [abs].

  26. Cropp, TA; McCafferty, DG, "Found in translation: applications of protein and peptide molecular diversity.", Current opinion in chemical biologyJune,, 2011, 15(3), 347-349 [doi].

  27. Hwang, S; Schmitt, AA; Luteran, AE; Toone, EJ; McCafferty, DG, "Thermodynamic characterization of the binding interaction between the histone demethylase LSD1/KDM1 and CoREST.", BiochemistryFebruary,, 2011, 50(4), 546-557 [21142040], [doi] [abs].

  28. Hu, X; Hu, H; Melvin, JA; Clancy, KW; McCafferty, DG; Yang, W, "Autocatalytic intramolecular isopeptide bond formation in gram-positive bacterial pili: a QM/MM simulation.", Journal of the American Chemical SocietyJanuary,, 2011, 133(3), 478-485 [21142157], [doi] [abs].

  29. Schmidt, JW; Greenough, A; Burns, M; Luteran, AE; McCafferty, DG, "Generation of ramoplanin-resistant Staphylococcus aureus.", FEMS microbiology lettersSeptember,, 2010, 310(2), 104-111 [20659164], [doi] [abs].

  30. Clancy, KW; Melvin, JA; McCafferty, DG, "Sortase transpeptidases: insights into mechanism, substrate specificity, and inhibition.", BiopolymersJanuary,, 2010, 94(4), 385-396 [20593474], [doi] [abs].

  31. Hamburger, JB; Hoertz, AJ; Lee, A; Senturia, RJ; McCafferty, DG; Loll, PJ, "A crystal structure of a dimer of the antibiotic ramoplanin illustrates membrane positioning and a potential Lipid II docking interface.", Proceedings of the National Academy of Sciences of the United States of AmericaAugust,, 2009, 106(33), 13759-13764 [19666597], [doi] [abs].

  32. Gaweska, H; Henderson Pozzi, M; Schmidt, DMZ; McCafferty, DG; Fitzpatrick, PF, "Use of pH and kinetic isotope effects to establish chemistry as rate-limiting in oxidation of a peptide substrate by LSD1.", BiochemistryJune,, 2009, 48(23), 5440-5445 [doi] [abs].

  33. Kudryavtsev, KV; Bentley, ML; McCafferty, DG, "Probing of the cis-5-phenyl proline scaffold as a platform for the synthesis of mechanism-based inhibitors of the Staphylococcus aureus sortase SrtA isoform.", Bioorganic & medicinal chemistryApril,, 2009, 17(7), 2886-2893 [doi] [abs].

  34. Deshmukh, HS; Hamburger, JB; Ahn, SH; McCafferty, DG; Yang, SR; Fowler, VG, "Critical role of NOD2 in regulating the immune response to Staphylococcus aureus.", Infect ImmunApril,, 2009, 77(4), 1376-1382 [19139201], [doi] [abs].

  35. Race, PR; Bentley, ML; Melvin, JA; Crow, A; Hughes, RK; Smith, WD; Sessions, RB; Kehoe, MA; McCafferty, DG; Banfield, MJ, "Crystal structure of Streptococcus pyogenes sortase A: implications for sortase mechanism.", The Journal of biological chemistryMarch,, 2009, 284(11), 6924-6933 [doi] [abs].

  36. Bentley, ML; Lamb, EC; McCafferty, DG, "Mutagenesis studies of substrate recognition and catalysis in the sortase A transpeptidase from Staphylococcus aureus.", The Journal of biological chemistryMay,, 2008, 283(21), 14762-14771 [doi] [abs].

  37. Gooden, DM; Schmidt, DMZ; Pollock, JA; Kabadi, AM; McCafferty, DG, "Facile synthesis of substituted trans-2-arylcyclopropylamine inhibitors of the human histone demethylase LSD1 and monoamine oxidases A and B.", Bioorganic & medicinal chemistry lettersMay,, 2008, 18(10), 3047-3051 [18242989], [doi] [abs].

  38. Frankel, BA; Tong, Y; Bentley, ML; Fitzgerald, MC; McCafferty, DG, "Mutational analysis of active site residues in the Staphylococcus aureus transpeptidase SrtA.", BiochemistryJune,, 2007, 46(24), 7269-7278 [doi] [abs].

  39. Schmidt, DMZ; McCafferty, DG, "trans-2-Phenylcyclopropylamine is a mechanism-based inactivator of the histone demethylase LSD1.", BiochemistryApril,, 2007, 46(14), 4408-4416 [17367163], [doi] [abs].

  40. Bentley, ML; Gaweska, H; Kielec, JM; McCafferty, DG, "Engineering the substrate specificity of Staphylococcus aureus Sortase A. The beta6/beta7 loop from SrtB confers NPQTN recognition to SrtA.", The Journal of biological chemistryMarch,, 2007, 282(9), 6571-6581 [doi] [abs].

  41. McCafferty, DG, "Crossing a biological velvet rope.", ACS chemical biologyJuly,, 2006, 1(6), 339-340 [17163767], [doi] [abs].

  42. Lee, MG; Wynder, C; Schmidt, DM; McCafferty, DG; Shiekhattar, R, "Histone H3 lysine 4 demethylation is a target of nonselective antidepressive medications.", Chemistry & biologyJune,, 2006, 13(6), 563-567 [doi] [abs].

  43. Frankel, BA; Kruger, RG; Robinson, DE; Kelleher, NL; McCafferty, DG, "Staphylococcus aureus sortase transpeptidase SrtA: insight into the kinetic mechanism and evidence for a reverse protonation catalytic mechanism.", BiochemistryAugust,, 2005, 44(33), 11188-11200 [doi] [abs].

  44. Barkallah, S; Schneider, SL; McCafferty, DG, "Facile syntheses of conformationally constrained analogues of lysine and homoglutamic acid", Tetrahedron LettersJuly,, 2005, 46(30), 4985-4987, Elsevier BV [doi] [abs].

  45. Gaweska, H; Kielec, J; McCafferty, D, "A suppression strategy for antibiotic discovery.", Chemistry & biologyOctober,, 2004, 11(10), 1330-1332 [doi] [abs].

  46. Kruger, RG; Barkallah, S; Frankel, BA; McCafferty, DG, "Inhibition of the Staphylococcus aureus sortase transpeptidase SrtA by phosphinic peptidomimetics.", Bioorganic & medicinal chemistryJuly,, 2004, 12(13), 3723-3729 [doi] [abs].

  47. Striplin, DR; Reece, SY; McCafferty, DG; Wall, CG; Friesen, DA; Erickson, BW; Meyer, TJ, "Solvent dependence of intramolecular electron transfer in a helical oligoproline assembly.", Journal of the American Chemical SocietyApril,, 2004, 126(16), 5282-5291 [doi] [abs].

  48. Kruger, RG; Dostal, P; McCafferty, DG, "Development of a high-performance liquid chromatography assay and revision of kinetic parameters for the Staphylococcus aureus sortase transpeptidase SrtA.", Analytical biochemistryMarch,, 2004, 326(1), 42-48 [doi] [abs].

  49. Frankel, BA; Bentley, M; Kruger, RG; McCafferty, DG, "Vinyl sulfones: inhibitors of SrtA, a transpeptidase required for cell wall protein anchoring and virulence in Staphylococcus aureus.", Journal of the American Chemical SocietyMarch,, 2004, 126(11), 3404-3405 [doi] [abs].

  50. Frankel, BA; McCafferty, DG, "Profiling natural product biosynthesis.", Chemistry & biologyMarch,, 2004, 11(3), 290-291 [doi] [abs].

  51. Kruger, RG; Otvos, B; Frankel, BA; Bentley, M; Dostal, P; McCafferty, DG, "Analysis of the substrate specificity of the Staphylococcus aureus sortase transpeptidase SrtA.", BiochemistryFebruary,, 2004, 43(6), 1541-1551 [doi] [abs].

  52. Loyola, A; He, S; Oh, S; McCafferty, DG; Reinberg, D, "Techniques used to study transcription on chromatin templates.", Methods in enzymologyJanuary,, 2004, 377, 474-499 [doi].

  53. He, S; Bauman, D; Davis, JS; Loyola, A; Nishioka, K; Gronlund, JL; Reinberg, D; Meng, F; Kelleher, N; McCafferty, DG, "Facile synthesis of site-specifically acetylated and methylated histone proteins: reagents for evaluation of the histone code hypothesis.", Proceedings of the National Academy of Sciences of the United States of AmericaOctober,, 2003, 100(21), 12033-12038 [doi] [abs].

  54. Kapustin, GV; Fejér, G; Gronlund, JL; McCafferty, DG; Seto, E; Etzkorn, FA, "Phosphorus-based SAHA analogues as histone deacetylase inhibitors.", Organic lettersAugust,, 2003, 5(17), 3053-3056 [doi] [abs].

  55. Huang, CY; He, S; DeGrado, WF; McCafferty, DG; Gai, F, "Light-induced helix formation", Journal of the American Chemical SocietyOctober,, 2002, 124(43), 12674-12675, American Chemical Society (ACS) [doi] [abs].

  56. Kruger, RG; Dostal, P; McCafferty, DG, "An economical and preparative orthogonal solid phase synthesis of fluorescein and rhodamine derivatized peptides: FRET substrates for the Staphylococcus aureus sortase SrtA transpeptidase reaction.", Chemical communications (Cambridge, England)September,, 2002, 2(18), 2092-2093, Royal Society of Chemistry (RSC) [doi] [abs].

  57. Cudic, P; Behenna, DC; Kranz, JK; Kruger, RG; Wand, AJ; Veklich, YI; Weisel, JW; McCafferty, DG, "Functional analysis of the lipoglycodepsipeptide antibiotic ramoplanin.", Chemistry & biologyAugust,, 2002, 9(8), 897-906 [doi] [abs].

  58. Cudic, P; Kranz, JK; Behenna, DC; Kruger, RG; Tadesse, H; Wand, AJ; Veklich, YI; Weisel, JW; McCafferty, DG, "Complexation of peptidoglycan intermediates by the lipoglycodepsipeptide antibiotic ramoplanin: minimal structural requirements for intermolecular complexation and fibril formation.", Proceedings of the National Academy of Sciences of the United States of AmericaMay,, 2002, 99(11), 7384-7389 [doi] [abs].

  59. McCafferty, DG; Cudic, P; Frankel, BA; Barkallah, S; Kruger, RG; Li, W, "Chemistry and biology of the ramoplanin family of peptide antibiotics.", BiopolymersJanuary,, 2002, 66(4), 261-284 [doi] [abs].

  60. Kruger, RG; Dostal, P; McCafferty, DG, "An economical and preparative orthogonal solid phase synthesis of fluorescein and rhodamine derivatized peptides: FRET substrates for the Staphylococcus aureus sortase SrtA transpeptidase reaction", Chemical Communications, 2002(18), 2092-2093 [abs].

  61. Cudic, P; Behenna, DC; Yu, MK; Kruger, RG; Szewczuk, LM; McCafferty, DG, "Synthesis of P(1)-Citronellyl-P(2)-alpha-D-pyranosyl pyrophosphates as potential substrates for the E. coli undecaprenyl-pyrophosphoryl-N-acetylglucoseaminyl transferase MurG.", Bioorganic & medicinal chemistry lettersDecember,, 2001, 11(24), 3107-3110 [doi] [abs].

  62. Bishop, BM; McCafferty, DG; Erickson, BW, "4'-Aminomethyl-2,2'-bipyridyl-4-carboxylic acid (Abc) and related derivatives: Novel bipyridine amino acids for the solid-phase incorporation of a metal coordination site within a peptide backbone", TetrahedronJune,, 2000, 56(27), 4629-4638, Elsevier BV [doi] [abs].

  63. McCafferty, DG; Cudic, P; Yu, MK; Behenna, DC; Kruger, R, "Synergy and duality in peptide antibiotic mechanisms.", Current opinion in chemical biologyDecember,, 1999, 3(6), 672-680 [doi] [abs].

  64. Lessard, IA; Pratt, SD; McCafferty, DG; Bussiere, DE; Hutchins, C; Wanner, BL; Katz, L; Walsh, CT, "Homologs of the vancomycin resistance D-Ala-D-Ala dipeptidase VanX in Streptomyces toyocaensis, Escherichia coli and Synechocystis: attributes of catalytic efficiency, stereoselectivity and regulation with implications for function.", Chemistry & biologySeptember,, 1998, 5(9), 489-504 [doi] [abs].

  65. McCafferty, DG; Lessard, IA; Walsh, CT, "Mutational analysis of potential zinc-binding residues in the active site of the enterococcal D-Ala-D-Ala dipeptidase VanX.", BiochemistryAugust,, 1997, 36(34), 10498-10505 [doi] [abs].

  66. McCafferty, DG; Friesen, DA; Danielson, E; Wall, CG; Saderholm, MJ; Erickson, BW; Meyer, TJ, "Photochemical energy conversion in a helical oligoproline assembly.", Proceedings of the National Academy of Sciences of the United States of AmericaAugust,, 1996, 93(16), 8200-8204 [doi] [abs].

  67. McCafferty, DG; Bishop, BM; Wall, CG; Hughes, SG; Mecklenberg, SL; Meyer, TJ; Erickson, BW, "Synthesis of redox derivatives of lysine and their use in solid-phase synthesis of a light-harvesting peptide", TetrahedronJanuary,, 1995, 51(4), 1093-1106 [doi] [abs].

  68. McCafferty, DG; Slate, CA; Nakhle, BM; Graham, HD; Austell, TL; Vachet, RW; Mullis, BH; Erickson, BW, "Engineering of a 129-residue tripod protein by chemoselective ligation of proline-II helices", TetrahedronJanuary,, 1995, 51(36), 9859-9872 [doi] [abs].

  69. Mecklenburg, SL; McCafferty, DG; Schoonover, JR; Peek, BM; Erickson, BW; Meyer, TJ, "Spectroscopic Study of Electron Transfer in a Trifunctional Lysine with Anthraquinone as the Electron Acceptor", Inorganic ChemistryJune,, 1994, 33(13), 2974-2983, American Chemical Society (ACS) [doi] [abs].

  70. Mecklenburg, SL; Peek, BM; Schoonover, JR; McCafferty, DG; Wall, CG; Erickson, BW; Meyer, TJ, "Photoinduced Electron Transfer in Amino Acid Assemblies", Journal of the American Chemical SocietyJune,, 1993, 115(13), 5479-5495, American Chemical Society (ACS) [doi] [abs].