Publications [#379781] of V. Joseph Hotz

Journal Articles

1. Perreira, KM; Hotz, VJ; Duke, NN; Aiello, AE; Belsky, DW; Brown, T; Jensen, T; Harris, KM, The Add Health Parent Study: A Biosocial Resource for the Study of Multigenerational Racial/Ethnic Disparities in Alzheimer's Disease and Alzheimer's Disease-Related Dementias., Journal of Alzheimer's disease : JAD, vol. 101 no. 2 (January, 2024), pp. 681-691 [doi]
   (last updated on 2026/01/21)

   Abstract:
   

   Background

   Alzheimer's disease and Alzheimer's disease related dementias (AD/ADRD) have increased in prevalence.

   Objective

   This article describes the Add Health Parent Study (AHPS) Phase 2, a study of social, behavioral, and biological factors influencing healthy aging and risk for AD/ADRD, in a national sample of adults aged 58-90.

   Methods

   Sample members are parents of the National Longitudinal Study of Adolescent to Adult Health (Add Health) cohort, initially interviewed in Add Health in midlife (1994-95). AHPS Phase 1 (2015-17) collected longitudinal data on a random subsample of parents and their spouse/partners, who were mostly Non-Hispanic (NH) White. AHPS Phase 2 will collect the same longitudinal socio-behavioral, and health survey data on all remaining NH Black and Hispanic parents (Black and Hispanic Supplement, BHS). Additionally, Phase 2 will collect cognitive and DNA data from AHPS Phase 1 and BHS sample parents and their current spouse/partners.

   Results

   Funded by the National Institute on Aging, recruitment will occur between June 2025 and May 2026, producing an expected total AHPS sample of 5506 parents and their spouse/partners.

   Conclusions

   The AHPS will be the first longitudinal cohort study powered to address multigenerational racial/ethnic disparities in AD/ADRD risk and protective factors across race/ethnic groups and socioeconomic strata.