Publications [#381274] of Seog Oh

Papers Published

1. Moloudi, R; Oh, S; Yang, C; Teo, KL; Lam, AT-L; Ebrahimi Warkiani, M; Win Naing, M, Scaled-Up Inertial Microfluidics: Retention System for Microcarrier-Based Suspension Cultures., Biotechnology journal, vol. 14 no. 5 (May, 2019), pp. e1800674 [doi]
   (last updated on 2026/01/21)

   Abstract:
   Recently, particle concentration and filtration using inertial microfluidics have drawn attention as an alternative to membrane and centrifugal technologies for industrial applications, where the target particle size varies between 1 µm and 500 µm. Inevitably, the bigger particle size (>50 µm) mandates scaling up the channel cross-section or hydraulic diameter (D_H > 0.5 mm). The Dean-coupled inertial focusing dynamics in spiral microchannels is studied broadly; however, the impacts of secondary flow on particle migration in a scaled-up spiral channel is not fully elucidated. The mechanism of particle focusing inside scaled-up rectangular and trapezoidal spiral channels (i.e., 5-10× bigger than conventional microchannels) with an aim to develop a continuous and clog-free microfiltration system for bioprocessing is studied in detail. Herein, a unique focusing based on inflection point without the aid of sheath flow is reported. This new focusing mechanism, observed in the scaled-up channels, out-performs the conventional focusing scenarios in the previously reported trapezoidal and rectangular channels. Finally, as a proof-of-concept, the utility of this device is showcased for the first time as a retention system for a cell-microcarrier (MC) suspension culture.