Publications [#381435] of Seog Oh

Papers Published

1. Park, C; Cho, I-H; Kim, D; Jo, E-K; Choi, S-Y; Oh, SB; Park, K; Kim, JS; Lee, SJ, Toll-like receptor 2 contributes to glial cell activation and heme oxygenase-1 expression in traumatic brain injury., Neuroscience letters, vol. 431 no. 2 (January, 2008), pp. 123-128 [doi]
   (last updated on 2026/01/20)

   Abstract:
   Traumatic brain injury is accompanied by glial cell activation around the site of the injury. In this study, we investigated the role of toll-like receptor 2 (TLR2) in glial cell activation using a stab-wound injury (SWI) model with TLR2 knock-out mice. Penetration of a normal mouse brain with a 26-G needle using a stereotaxic instrument resulted in an 18- and 4-fold upregulation of GFAP and CD11b mRNA, respectively, along the needle track in the injury area. However, in the TLR2 knock-out mice, the induced expression of these genes was reduced by 70% and 40%, respectively. Likewise, there was a reduction in the area of activated glial cells detected by immunohistochemistry and the glial cells had a less-activated morphology in the TLR2 knock-out mice. In addition, the expression of the heme oxygenase-1 (HO-1) gene, a glia-expressing wound-responsive gene, was reduced after SWI in TLR2 knock-out mice. Taken together, these data argue that TLR2 contributes to the glial cell activation and HO-1 gene expression associated with traumatic brain injury.