Publications [#381440] of Seog Oh

Papers Published

1. Li, HY; Park, C-K; Jung, SJ; Choi, S-Y; Lee, SJ; Park, K; Kim, JS; Oh, SB, Eugenol inhibits K+ currents in trigeminal ganglion neurons., Journal of dental research, vol. 86 no. 9 (September, 2007), pp. 898-902 [doi]
   (last updated on 2026/01/19)

   Abstract:
   

   Unlabelled

   Eugenol, a natural capsaicin congener, is widely used in dentistry. Eugenol inhibits voltage-activated Na(+) and Ca(2+) channels in a transient receptor potential vanilloid 1 (TRPV1)-independent manner. We hypothesized that eugenol also inhibits voltage-gated K(+) currents, and investigated this in rat trigeminal ganglion neurons and in a heterologous system using whole-cell patch clamping. Eugenol inhibited voltage-gated K(+) currents, and the inhibitory effects of eugenol were observed in both capsaicin-sensitive and capsaicin-insensitive neurons. Pre-treatment with capsazepine, a well-known antagonist of TRPV1, failed to block the inhibitory effects of eugenol on K(+) currents, suggesting no involvement of TRPV1. Eugenol inhibited human Kv1.5 currents stably expressed in Ltk(-) cells, where TRPV1 is not endogenously expressed. We conclude that eugenol inhibits voltage-gated K(+) currents in a TRPV1-independent manner. The inhibition of voltage-gated K(+) currents is likely to contribute to the irritable action of eugenol.

   Abbreviations

   human Kv1.5 channel, hKv1.5; transient receptor potential vanilloid 1, TRPV1.