Publications [#381474] of Seog Oh

Papers Published

1. Yeon, K-Y; Sim, M-Y; Choi, S-Y; Lee, SJ; Park, K; Kim, JS; Lee, J-H; Lee, K-M; Oh, SB, Molecular mechanisms underlying calcium current modulation by nociceptin., Neuroreport, vol. 15 no. 14 (October, 2004), pp. 2205-2209 [doi]
   (last updated on 2026/01/20)

   Abstract:
   Nociceptin is a non-opioid peptide that modulates pain response. One of mechanism underlying its analgesic action is the inhibition of voltage-dependent calcium current (ICa), similar to that of opioids. We investigated the molecular mechanism by which nociceptin inhibits ICa using sensory neurons and a heterologous expression system. ICa inhibition by nociceptin was voltage-dependent, exhibited the slowing of activation kinetics and prepulse facilitation, and was blocked by N-ethylmaleimide, indicating the involvement of Gi/Go protein. ICa inhibition by nociceptin was primarily mediated through binding to its own receptor, ORL-1, but not through affecting other mu-opioid receptors. Thus, our results strongly demonstrate that heterologous cross-talk between ORL1 and muOR is not involved in the ICa inhibition by nociceptin.