Publications [#381477] of Seog Oh

Papers Published

1. Oh, SB; Piao, ZG; Shin, SS; Ren, D; Park, K; Kim, JS, GABAergic and serotonergic modulation of calcium currents in rat trigeminal motoneurons., Biochemical and biophysical research communications, vol. 309 no. 1 (September, 2003), pp. 58-65 [doi]
   (last updated on 2026/01/20)

   Abstract:
   We investigated the effects of a GABA(B) agonist baclofen, and serotonin, on the high voltage-activated Ca channel (HVACC) currents in trigeminal motoneurons. Immunohistochemical and reverse transcription-polymerization chain reaction (RT-PCR) studies demonstrated the expression of alpha(1C), alpha(1B), alpha(1A), and alpha(1E) subunits in the trigeminal motoneurons, which form L-, N-, P/Q-, and R-type Ca channels, respectively. By use of specific Ca blockers, it was found that N-type (38%), P/Q-type (27%), L-type (16 %), and R-type Ca currents (19%) contribute to HVACC I(Ba). Baclofen inhibited HVACC I(Ba) in the majority of trigeminal motoneurons tested (n=15 out of 16), whereas serotonin only did in a small population (n=5 out of 18). The I(Ba) inhibition by baclofen and serotonin was associated with slowing of activation kinetics, relieved by strong prepulse, and prevented by N-ethylmaleimide (NEM), indicative of mediation of Gi/Go. These data provide evidence that GABAergic and serotonergic inputs to trigeminal motoneurons regulate neuronal activities through the inhibition of HVACC currents.