Publications [#381481] of Seog Oh

Papers Published

1. Oh, SB; Endoh, T; Simen, AA; Ren, D; Miller, RJ, Regulation of calcium currents by chemokines and their receptors., Journal of neuroimmunology, vol. 123 no. 1-2 (February, 2002), pp. 66-75 [doi]
   (last updated on 2026/01/20)

   Abstract:
   We investigated the modulation of voltage dependent Ca(2+) currents by chemokine receptors in heterologous expression systems and neurons. Fractalkine, SDF-1alpha, RANTES and MDC inhibited the I(Ba) in CX3CR1-, CXCR4-, CCR5- and CCR4-expressing G1A1 cells, respectively. The I(Ba) inhibition was voltage-dependent, exhibited prepulse facilitation, and was blocked by N-ethylmaleimide and pertussis toxin pretreatment, indicating that it was mediated by Gi/Go. Some chemokines also inhibited the I(Ba) in subpopulations of dorsal root ganglion neurons and area postrema/nucleus tractus solitarius neurons. These data provide evidence that chemokines can potentially modulate neuronal signaling through the inhibition of neuronal Ca(2+) currents.