Publications [#373984] of Amanda Randles

Papers Published

1. Roychowdhury, S; Mahmud, ST; Puleri, DF; Lai, A; Rex, R; Li, B; Sohn, LL; Randles, A, DEVELOPING A DIGITAL TWIN FOR SINGLE-CELL MECHANICAL PHENOTYPING MICROFLUIDIC DEVICES, Microtas 2022 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences (January, 2022), pp. 831-832, ISBN 9781733419048
   (last updated on 2025/12/31)

   Abstract:
   Microfluidics can be used to characterize individual cells in a population based on their mechanical traits. In this work, we digitally replicate the microfluidic device developed by Li et al. [1] and perform simulations of a representative AP-1060 cell. We show that the numerical model is able to recover whole-cell deformability index, a metric used to quantify the resistance of cells to compressive deformation, within 3% of the experimental average. These results pave the way for future studies which utilize experimental and computational approaches to optimize geometric design parameters, complement signal analysis, and enhance the acquisition of mechanical information.