Publications [#383673] of Amanda Randles

Papers Published

1. Jensen, C; Ghorbannia, A; Urick, D; Hughes, GC; Randles, A, A systematic quantification of hemodynamic differences persisting after aortic coarctation repair., Front Bioeng Biotechnol, vol. 13 (2025), pp. 1539256, Frontiers Media S.A. [doi]
   (last updated on 2025/12/31)

   Abstract:
   INTRODUCTION: Aortic coarctation (CoA) comprises 6%-8% of all congenital heart diseases and is the second most common cardiovascular disease requiring neonatal surgical correction. However, patients remain at high risk for long-term complications, notably recoarctation. METHODS: Hemodynamic simulations were performed in a group of six patients following CoA repair, as compared to a group of age and sex-matched healthy controls. Progressive narrowing at the CoA repair site was modeled to simulate the recoarctation process. Key measurements included time-averaged wall shear stress (TAWSS) in the aortic arch and CoA repair site. RESULTS: Repaired aortas demonstrated significantly higher TAWSS compared to healthy aortas in the aortic arch (3.46 vs 1.24 Pa, p < 0.05) and CoA repair site (4.34 vs 1.56 Pa, p < 0.05). A pronounced nonlinear relationship between stenosis severity and TAWSS was observed suggesting that increasing stenosis corresponds to progressively abnormal shear stress. DISCUSSION: The persistent high TAWSS in CoA-repaired aortas may underlie the poor long-term outcomes observed in this population. The identified nonlinear relationship between stenosis severity and TAWSS magnitude suggests a potential positive feedback mechanism, where abnormal shear stress exacerbates pathologic remodeling in the repaired aorta, highlighting the potential role of hemodynamic simulations in the clinical management of CoA patients.