Publications [#221611] of Ahmad Hariri

Journal Articles

1. Fisher, P. M. and Meltzer, C. C. and Ziolko, S. K. and Price, J. C. and Moses-Kolko, E. L. and Berga, S. L. and Hariri, A. R. (2006). Capacity for 5-HT1A-mediated autoregulation predicts amygdala reactivity. Nature neuroscience, 9(11), 1362--3. [17013380], [doi]
   (last updated on 2013/12/23)

   Abstract:
   We examined the contribution of 5-HT1A autoreceptors (with [11C]WAY100635 positron emission tomography) to amygdala reactivity (with blood oxygenation level-dependent functional magnetic resonance imaging) in 20 healthy adult volunteers. We found a significant inverse relationship wherein 5-HT1A autoreceptor density predicted a notable 30-44\% of the variability in amygdala reactivity. Our data suggest a potential molecular mechanism by which a reduced capacity for negative feedback regulation of 5-HT release is associated with increased amygdala reactivity.