Publications [#252118] of Ahmad Hariri

Journal Articles

1. Wang, AT; Dapretto, M; Hariri, AR; Sigman, M; Bookheimer, SY (2004). Neural correlates of facial affect processing in children and adolescents with autism spectrum disorder.. Journal of the American Academy of Child and Adolescent Psychiatry, 43(4), 481-490. [15187809], [doi]
   (last updated on 2024/04/24)

   Abstract:
   

   Objective

   To examine the neural basis of impairments in interpreting facial emotions in children and adolescents with autism spectrum disorders (ASD).

   Method

   Twelve children and adolescents with ASD and 12 typically developing (TD) controls matched faces by emotion and assigned a label to facial expressions while undergoing functional magnetic resonance imaging.

   Results

   Both groups engaged similar neural networks during facial emotion processing, including activity in the fusiform gyrus (FG) and prefrontal cortex. However, between-group analyses in regions of interest revealed that when matching facial expressions, the ASD group showed significantly less activity than the TD group in the FG, but reliably greater activity in the precuneus. During the labeling of facial emotions, no between-group differences were observed at the behavioral or neural level. Furthermore, activity in the amygdala was moderated by task demands in the TD group but not in the ASD group.

   Conclusions

   These findings suggest that children and adolescents with ASD in part recruit different neural networks and rely on different strategies when processing facial emotions. High-functioning individuals with ASD may be relatively unimpaired in the cognitive assessment of basic emotions, yet still show differences in the automatic processing of facial expressions.