Publications [#371656] of Ahmad Hariri

Journal Articles

1. Whitman, ET; Knodt, AR; Elliott, ML; Abraham, WC; Cheyne, K; Hogan, S; Ireland, D; Keenan, R; Leung, JH; Melzer, TR; Poulton, R; Purdy, SC; Ramrakha, S; Thorne, PR; Caspi, A; Moffitt, TE; Hariri, AR (2023). Functional topography of the neocortex predicts covariation in complex cognitive and basic motor abilities.. Cerebral cortex (New York, N.Y. : 1991), 33(13), 8218-8231. [doi]
   (last updated on 2025/06/16)

   Abstract:
   Although higher-order cognitive and lower-order sensorimotor abilities are generally regarded as distinct and studied separately, there is evidence that they not only covary but also that this covariation increases across the lifespan. This pattern has been leveraged in clinical settings where a simple assessment of sensory or motor ability (e.g. hearing, gait speed) can forecast age-related cognitive decline and risk for dementia. However, the brain mechanisms underlying cognitive, sensory, and motor covariation are largely unknown. Here, we examined whether such covariation in midlife reflects variability in common versus distinct neocortical networks using individualized maps of functional topography derived from BOLD fMRI data collected in 769 45-year-old members of a population-representative cohort. Analyses revealed that variability in basic motor but not hearing ability reflected individual differences in the functional topography of neocortical networks typically supporting cognitive ability. These patterns suggest that covariation in motor and cognitive abilities in midlife reflects convergence of function in higher-order neocortical networks and that gait speed may not be simply a measure of physical function but rather an integrative index of nervous system health.