Publications [#177524] of Bruce A Sullenger

Papers Published

1. J Mi, Y Liu, ZN Rabbani, Z Yang, JH Urban, BA Sullenger, BM Clary, In vivo selection of tumor-targeting RNA motifs., Nature chemical biology, vol. 6 no. 1 (January, 2010), pp. 22-4, ISSN 1552-4469 [doi]
   (last updated on 2013/05/16)

   Abstract:
   In an effort to target the in vivo context of tumor-specific moieties, we screened a large library of nuclease-resistant RNA oligonucleotides in tumor-bearing mice to identify candidate molecules with the ability to localize to hepatic colon cancer metastases. One of the selected molecules is an RNA aptamer that binds to p68, an RNA helicase that has been shown to be upregulated in colorectal cancer.

   Keywords:
   Animals • Aptamers, Nucleotide • COS Cells • Cell Line, Tumor • Cercopithecus aethiops • Colonic Neoplasms • DEAD-box RNA Helicases • Gene Expression Regulation, Neoplastic* • Genetic Techniques • Humans • Kinetics • Liver Neoplasms • Mice • Neoplasm Metastasis • Neoplasms • Oligonucleotides • RNA • chemistry • genetics* • metabolism* • pathology* • secondary* • therapy*