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Bruce A Sullenger, Professor of Surgery and Director of the Duke Center for Translational Research

Bruce A Sullenger
Contact Info:
Office Location:  DUMC 103035
Office Phone:  (919) 684-6375
Email Address: send me a message
Web Page:  http://sciences.surgery.duke.edu/research/institutes-and-labs/cardiovascular-biology

Education:

Ph.D.Cornell University1990

Representative Publications   (More Publications)

  1. SK Buddai, JM Layzer, G Lu, CP Rusconi, BA Sullenger, DM Monroe, S Krishnaswamy, An anticoagulant RNA aptamer that inhibits proteinase-cofactor interactions within prothrombinase., The Journal of biological chemistry, vol. 285 no. 8 (February, 2010), pp. 5212-23, ISSN 1083-351X [doi]  [abs]
  2. J Mi, Y Liu, ZN Rabbani, Z Yang, JH Urban, BA Sullenger, BM Clary, In vivo selection of tumor-targeting RNA motifs., Nature chemical biology, vol. 6 no. 1 (January, 2010), pp. 22-4, ISSN 1552-4469 [doi]  [abs]
  3. J Wang, TP Wakeman, JD Lathia, AB Hjelmeland, XF Wang, RR White, JN Rich, BA Sullenger, Notch promotes radioresistance of glioma stem cells., Stem cells (Dayton, Ohio), vol. 28 no. 1 (January, 2010), pp. 17-28, ISSN 1549-4918 [doi]  [abs]
  4. S Oney, RT Lam, KM Bompiani, CM Blake, G Quick, JD Heidel, JY Liu, BC Mack, ME Davis, KW Leong, BA Sullenger, Development of universal antidotes to control aptamer activity., Nature medicine, vol. 15 no. 10 (October, 2009), pp. 1224-8, ISSN 1546-170X [doi]  [abs]
  5. CM Blake, BA Sullenger, DA Lawrence, YM Fortenberry, Antimetastatic potential of PAI-1-specific RNA aptamers., Oligonucleotides, vol. 19 no. 2 (June, 2009), pp. 117-28, ISSN 1557-8526 [doi]  [abs]
  6. SB Long, MB Long, RR White, BA Sullenger, Crystal structure of an RNA aptamer bound to thrombin., RNA (New York, N.Y.), vol. 14 no. 12 (December, 2008), pp. 2504-12, ISSN 1469-9001 [doi]  [abs]
  7. CM Dollins, S Nair, D Boczkowski, J Lee, JM Layzer, E Gilboa, BA Sullenger, Assembling OX40 aptamers on a molecular scaffold to create a receptor-activating aptamer., Chemistry & biology, vol. 15 no. 7 (July, 2008), pp. 675-82, ISSN 1074-5521 [doi]  [abs]
  8. PH Giangrande, J Zhang, A Tanner, AD Eckhart, RE Rempel, ER Andrechek, JM Layzer, JR Keys, PO Hagen, JR Nevins, WJ Koch, BA Sullenger, Distinct roles of E2F proteins in vascular smooth muscle cell proliferation and intimal hyperplasia., Proceedings of the National Academy of Sciences of the United States of America, vol. 104 no. 32 (August, 2007), pp. 12988-93, ISSN 0027-8424 [doi]  [abs]
  9. MN Kierlin-Duncan, BA Sullenger, Using 5'-PTMs to repair mutant beta-globin transcripts., RNA (New York, N.Y.), vol. 13 no. 8 (August, 2007), pp. 1317-27, ISSN 1355-8382 [doi]  [abs]
  10. SM Nimjee, JR Keys, GA Pitoc, G Quick, CP Rusconi, BA Sullenger, A novel antidote-controlled anticoagulant reduces thrombin generation and inflammation and improves cardiac function in cardiopulmonary bypass surgery., Molecular therapy : the journal of the American Society of Gene Therapy, vol. 14 no. 3 (September, 2006), pp. 408-15, ISSN 1525-0016 [doi]  [abs]
  11. JO McNamara 2nd, ER Andrechek, Y Wang, KD Viles, RE Rempel, E Gilboa, BA Sullenger, PH Giangrande, Cell type-specific delivery of siRNAs with aptamer-siRNA chimeras., Nature biotechnology, vol. 24 no. 8 (August, 2006), pp. 1005-15, ISSN 1087-0156 [doi]  [abs]
  12. JP Jones 3rd, MN Kierlin, RG Coon, J Perutka, AM Lambowitz, BA Sullenger, Retargeting mobile group II introns to repair mutant genes., Molecular therapy : the journal of the American Society of Gene Therapy, vol. 11 no. 5 (May, 2005), pp. 687-94, ISSN 1525-0016 [doi]  [abs]
  13. SM Nimjee, CP Rusconi, BA Sullenger, Aptamers: an emerging class of therapeutics., Annual review of medicine, vol. 56 (2005), pp. 555-83, ISSN 0066-4219 [doi]  [abs]
  14. CP Rusconi, JD Roberts, GA Pitoc, SM Nimjee, RR White, G Quick Jr, E Scardino, WP Fay, BA Sullenger, Antidote-mediated control of an anticoagulant aptamer in vivo., Nature biotechnology, vol. 22 no. 11 (November, 2004), pp. 1423-8, ISSN 1087-0156 [doi]  [abs]
  15. JM Layzer, AP McCaffrey, AK Tanner, Z Huang, MA Kay, BA Sullenger, In vivo activity of nuclease-resistant siRNAs., RNA (New York, N.Y.), vol. 10 no. 5 (May, 2004), pp. 766-71, ISSN 1355-8382  [abs]
  16. J Byun, N Lan, M Long, BA Sullenger, Efficient and specific repair of sickle beta-globin RNA by trans-splicing ribozymes., RNA (New York, N.Y.), vol. 9 no. 10 (October, 2003), pp. 1254-63, ISSN 1355-8382  [abs]
  17. RR White, S Shan, CP Rusconi, G Shetty, MW Dewhirst, CD Kontos, BA Sullenger, Inhibition of rat corneal angiogenesis by a nuclease-resistant RNA aptamer specific for angiopoietin-2., Proceedings of the National Academy of Sciences of the United States of America, vol. 100 no. 9 (April, 2003), pp. 5028-33, ISSN 0027-8424 [doi]  [abs]
  18. CS Rogers, CG Vanoye, BA Sullenger, AL George Jr, Functional repair of a mutant chloride channel using a trans-splicing ribozyme., The Journal of clinical investigation, vol. 110 no. 12 (December, 2002), pp. 1783-9, ISSN 0021-9738 [doi]  [abs]
  19. CP Rusconi, E Scardino, J Layzer, GA Pitoc, TL Ortel, D Monroe, BA Sullenger, RNA aptamers as reversible antagonists of coagulation factor IXa., Nature, vol. 419 no. 6902 (September, 2002), pp. 90-4, ISSN 0028-0836 [doi]  [abs]
  20. RE Martell, JR Nevins, BA Sullenger, Optimizing aptamer activity for gene therapy applications using expression cassette SELEX., Molecular therapy : the journal of the American Society of Gene Therapy, vol. 6 no. 1 (July, 2002), pp. 30-4, ISSN 1525-0016  [abs]
  21. BA Sullenger, E Gilboa, Emerging clinical applications of RNA., Nature, vol. 418 no. 6894 (July, 2002), pp. 252-8, ISSN 0028-0836 [doi]  [abs]
  22. Nimje,S. and Sullenger, B.A.(2002)the Sabiston Vision of Basic Science in a Department of Surgery.  Annals of Surgery, In Press.
  23. Sullenger,B.A., White,R.R. and Rusconi,C.P.(2002)Therapeutic Aptamers and Antidotes: A Novel Approach to Safer Drug Design. In Ernst Schering Research Foundation Symposium Series.
  24. CP Rusconi, A Yeh, HK Lyerly, JH Lawson, BA Sullenger, Blocking the initiation of coagulation by RNA aptamers to factor VIIa., Thrombosis and haemostasis, vol. 84 no. 5 (November, 2000), pp. 841-8, ISSN 0340-6245  [abs]
  25. T Watanabe, BA Sullenger, RNA repair: a novel approach to gene therapy., Advanced drug delivery reviews, vol. 44 no. 2-3 (November, 2000), pp. 109-18, ISSN 0169-409X  [abs]
  26. BA Sullenger, Series introduction: emerging clinical applications of nucleic acids, The Journal of clinical investigation, vol. 106 no. 8 (October, 2000), pp. 921-2, ISSN 1558-8238 [doi]
  27. RR White, BA Sullenger, CP Rusconi, Developing aptamers into therapeutics., The Journal of clinical investigation, vol. 106 no. 8 (October, 2000), pp. 929-34, ISSN 0021-9738 [doi]
  28. N Lan, BL Rooney, SW Lee, RP Howrey, CA Smith, BA Sullenger, Enhancing RNA repair efficiency by combining trans-splicing ribozymes that recognize different accessible sites on a target RNA., Molecular therapy : the journal of the American Society of Gene Therapy, vol. 2 no. 3 (September, 2000), pp. 245-55, ISSN 1525-0016 [doi]  [abs]
  29. T Watanabe, BA Sullenger, Induction of wild-type p53 activity in human cancer cells by ribozymes that repair mutant p53 transcripts., Proceedings of the National Academy of Sciences of the United States of America, vol. 97 no. 15 (July, 2000), pp. 8490-4, ISSN 0027-8424 [doi]  [abs]
  30. MB Long, BA Sullenger, Evaluating group I intron catalytic efficiency in mammalian cells., Molecular and cellular biology, vol. 19 no. 10 (October, 1999), pp. 6479-87, ISSN 0270-7306  [abs]
  31. BA Sullenger, RNA repair as a novel approach to genetic therapy., Gene therapy, vol. 6 no. 4 (April, 1999), pp. 461-2, ISSN 0969-7128 [doi]
  32. PP Zarrinkar, BA Sullenger, Optimizing the substrate specificity of a group I intron ribozyme., Biochemistry, vol. 38 no. 11 (March, 1999), pp. 3426-32, ISSN 0006-2960 [doi]  [abs]
  33. PP Zarrinkar, BA Sullenger, Probing the interplay between the two steps of group I intron splicing: competition of exogenous guanosine with omega G., Biochemistry, vol. 37 no. 51 (December, 1998), pp. 18056-63, ISSN 0006-2960  [abs]
  34. N Lan, RP Howrey, SW Lee, CA Smith, BA Sullenger, Ribozyme-mediated repair of sickle beta-globin mRNAs in erythrocyte precursors., Science (New York, N.Y.), vol. 280 no. 5369 (June, 1998), pp. 1593-6, ISSN 0036-8075  [abs]
  35. JT Jones, BA Sullenger, Evaluating and enhancing ribozyme reaction efficiency in mammalian cells., Nature biotechnology, vol. 15 no. 9 (September, 1997), pp. 902-5, ISSN 1087-0156 [doi]  [abs]
  36. SW Lee, BA Sullenger, Isolation of a nuclease-resistant decoy RNA that can protect human acetylcholine receptors from myasthenic antibodies., Nature biotechnology, vol. 15 no. 1 (January, 1997), pp. 41-5, ISSN 1087-0156 [doi]  [abs]
  37. 1. Lee, S.-W. and Sullenger, B. A. (1997). Isolation of a nuclease resistant decoy RNA that can protect human acetylcholine receptors from myasthenic antibodies. Nature Biotechnology, 15, 41-45.
  38. 2. Jones, J. T. and Sullenger, B. A. (1997). Evaluating and enhancing ribozyme reaction efficiency in mammalian cells. Nature Biotechnology 15, 902-905..
  39. 3. Jones, J. T., Lee, S.-W., and Sullenger, B. A. (1997). Trans-splicing reactions by ribozymes. In Methods in Molecular Biology. Vol. 74: Ribozyme Protocols (ed. Turner, P.), pp. 341-348. 4. Milich, L and Sullenger, B. A. (1997). Ribozymes as tools for the gene therapist. In Concepts in Gene Therapy (eds. Strauss, M. and Barranger, J.A.) pp. 195-227.
  40. 5. Sullenger, B. A. (1997). RNA repair: The next wave of gene therapy. J. NIH Research 9, 37-40.
  41. JT Jones, SW Lee, BA Sullenger, Trans-splicing reactions by ribozymes., Methods in molecular biology (Clifton, N.J.), vol. 74 (1997), pp. 341-8, ISSN 1064-3745 [doi]
  42. J Ishizaki, JR Nevins, BA Sullenger, Inhibition of cell proliferation by an RNA ligand that selectively blocks E2F function., Nature medicine, vol. 2 no. 12 (December, 1996), pp. 1386-9, ISSN 1078-8956  [abs]
  43. BA Sullenger, Ribozyme-mediated repair of RNAs encoding mutant tumor suppressors., Cytokines and molecular therapy, vol. 2 no. 3 (September, 1996), pp. 201-5, ISSN 1355-6568  [abs]
  44. SW Lee, BA Sullenger, Isolation of a nuclease-resistant decoy RNA that selectively blocks autoantibody binding to insulin receptors on human lymphocytes., The Journal of experimental medicine, vol. 184 no. 2 (August, 1996), pp. 315-24, ISSN 0022-1007  [abs]
  45. JT Jones, SW Lee, BA Sullenger, Tagging ribozyme reaction sites to follow trans-splicing in mammalian cells., Nature medicine, vol. 2 no. 6 (June, 1996), pp. 643-8, ISSN 1078-8956  [abs]
  46. 4. Jones, J. T., Lee S.-W., and Sullenger, B. A. (1996). Tagging ribozyme reaction sites to follow trans-splicing in mammalian cells. Nature Medicine 2, 643-648.
  47. Jones, J. T., Lee, S.-W., and Sullenger, B. A.: Trans-splicing reactions by ribozymes. In Press 1996.
  48. Sullenger, B. A.: Ribozyme-mediated repair of RNAs encoding mutant tumor suppressors. In Press 1996.
  49. BA Sullenger, Revising messages traveling along the cellular information superhighway., Chemistry & biology, vol. 2 no. 5 (May, 1995), pp. 249-53, ISSN 1074-5521  [abs]
  50. JA Doudna, TR Cech, BA Sullenger, Selection of an RNA molecule that mimics a major autoantigenic epitope of human insulin receptor., Proceedings of the National Academy of Sciences of the United States of America, vol. 92 no. 6 (March, 1995), pp. 2355-9, ISSN 0027-8424  [abs]
  51. Cambell, T. B. and Sullenger, B. A.: The use of ribozymes as antiviral agents. Advances in Pharmacology 33. 143-178, 1995.
  52. TB Campbell, BA Sullenger, Alternative approaches for the application of ribozymes as gene therapies for retroviral infections., Advances in pharmacology (San Diego, Calif.), vol. 33 (1995), pp. 143-78, ISSN 1054-3589
  53. Smith, C. and Sullenger, B. A.: Aids and HIV infection. In Molecular and Cell Biology of Human Gene Therapeutics. Ed. Dickson, G. Chapman and Hall, London, pp.195-236, 1995.
  54. C Smith, BA Sullenger, AIDS and HIV infection., Molecular and cell biology of human diseases series, vol. 5 (1995), pp. 195-236, ISSN 1470-0573
  55. Sullenger, B. A. and Cech, T. R.: RNA repair: a new possibility for gene therapy. The Journal of NIH Research 7, 46-47, 1995.
  56. Sullenger, B. A.: Adapting ribozymes to be gene inhibitors. Applied Biochemistry and Biotechnology 54, 57-61, 1995.
  57. Sullenger, B. A.: RNA Repair: revising messages traveling along the cellular information superhighway. Chemistry & Biology 2, 249-253, 1995.
  58. BA Sullenger, Colocalizing ribozymes with substrate RNAs to increase their efficacy as gene inhibitors., Applied biochemistry and biotechnology, vol. 54 no. 1-3 (December, 1995), pp. 57-61, ISSN 0273-2289  [abs]
  59. BA Sullenger, TR Cech, Ribozyme-mediated repair of defective mRNA by targeted, trans-splicing., Nature, vol. 371 no. 6498 (October, 1994), pp. 619-22, ISSN 0028-0836 [doi]  [abs]
  60. Sullenger, B. A. and Cech, T. R.: Ribozyme-mediated repair of defective mRNA by targeted trans-splicing. Nature 317, 619-622, 1994.
  61. BA Sullenger, TR Cech, Tethering ribozymes to a retroviral packaging signal for destruction of viral RNA., Science (New York, N.Y.), vol. 262 no. 5139 (December, 1993), pp. 1566-9, ISSN 0036-8075  [abs]
  62. 2. Sullenger, B. A. and Cech, T. R. (1993). Tethering ribozymes to a retroviral packaging signal for destruction of viral RNA. Science 262, 1566-1569.
  63. Sullenger, B. A. and Cech, T. R.: Tethering ribozymes to a retroviral packaging signal for destruction of viral RNA. Science 262, 1566-1569, 1993.
  64. TC Lee, BA Sullenger, HF Gallardo, GE Ungers, E Gilboa, Overexpression of RRE-derived sequences inhibits HIV-1 replication in CEM cells., The New biologist, vol. 4 no. 1 (January, 1992), pp. 66-74, ISSN 1043-4674  [abs]
  65. BA Sullenger, HF Gallardo, GE Ungers, E Gilboa, Analysis of trans-acting response decoy RNA-mediated inhibition of human immunodeficiency virus type 1 transactivation., Journal of virology, vol. 65 no. 12 (December, 1991), pp. 6811-6, ISSN 0022-538X  [abs]
  66. BA Sullenger, TC Lee, CA Smith, GE Ungers, E Gilboa, Expression of chimeric tRNA-driven antisense transcripts renders NIH 3T3 cells highly resistant to Moloney murine leukemia virus replication., Molecular and cellular biology, vol. 10 no. 12 (December, 1990), pp. 6512-23, ISSN 0270-7306  [abs]
  67. BA Sullenger, HF Gallardo, GE Ungers, E Gilboa, Overexpression of TAR sequences renders cells resistant to human immunodeficiency virus replication., Cell, vol. 63 no. 3 (November, 1990), pp. 601-8, ISSN 0092-8674  [abs]
  68. 1. Sullenger, B. A., Gallardo, H. F., Ungers, G. E., and Gilboa, E. (1990). Overexpression of TAR sequences renders cells resistant to human immunodeficiency virus replication. Cell 63, 601-608.
  69. PA Hantzopoulos, BA Sullenger, G Ungers, E Gilboa, Improved gene expression upon transfer of the adenosine deaminase minigene outside the transcriptional unit of a retroviral vector., Proceedings of the National Academy of Sciences of the United States of America, vol. 86 no. 10 (May, 1989), pp. 3519-23, ISSN 0027-8424  [abs]

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