Publications [#99833] of Bruce A Sullenger

Papers Published

1. SW Lee, BA Sullenger, Isolation of a nuclease-resistant decoy RNA that can protect human acetylcholine receptors from myasthenic antibodies., Nature biotechnology, vol. 15 no. 1 (January, 1997), pp. 41-5, ISSN 1087-0156 [doi]
   (last updated on 2013/05/16)

   Abstract:
   The muscular weakness and fatigability associated with myasthenia gravis are engendered by autoantibodies directed against acetylcholine receptors on muscle cells at neuromuscular junctions. The pathogenic consequences of this immune response can potentially be modulated by molecules that bind such autoantibodies and block their interaction with these receptors. We report the isolation of a small nuclease-resistant RNA molecule that binds both a rat monoclonal antibody that recognizes the main immunogenic region on the acetylcholine receptor, and autoantibodies from patients with myasthenia gravis. Moreover, this RNA can act as a decoy and protect acetylcholine receptors on human cells from the effects of these antibodies.

   Keywords:
   Animals • Antibodies, Monoclonal • Autoantibodies • Base Sequence • Binding Sites • Cloning, Molecular • Down-Regulation • Epitopes • Humans • Molecular Sequence Data • Myasthenia Gravis • RNA • Rats • Receptors, Cholinergic • Rhabdomyosarcoma • Ribonucleases • Substrate Specificity • Tumor Cells, Cultured • drug effects • drug therapy • immunology • immunology* • metabolism • metabolism* • methods • pathology • pharmacology