Center for Biomolecular and Tissue Engineering Center for Biomolecular and Tissue Engineering
Pratt School of Engineering
Duke University
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Christopher D. Kontos, Associate Professor of Medicine

Christopher D. Kontos
Contact Info:
Office Location:  180A CARL Building
Office Phone:  (919) 684-2119, (919) 684-4562
Email Address: send me a message
Web Page:  http://people.duke.edu/~cdkontos/Kontos_Lab/Home.html

Education:

M.D.Virginia Commonwealth University1989

Representative Publications   (More Publications)

  1. A Ahmed, T Fujisawa, XL Niu, S Ahmad, B Al-Ani, K Chudasama, A Abbas, R Potluri, V Bhandari, CM Findley, GK Lam, J Huang, PW Hewett, M Cudmore, CD Kontos, Angiopoietin-2 confers Atheroprotection in apoE-/- mice by inhibiting LDL oxidation via nitric oxide., Circulation research, vol. 104 no. 12 (June, 2009), pp. 1333-6, ISSN 1524-4571 [doi]  [abs]
  2. D Xie, CM Findley, JM Greenfield, AM Pippen, CD Kontos, CF Donatucci, BH Annex, A VEGF trap inhibits the beneficial effect of bFGF on vasoreactivity in corporal tissues of hypercholesterolemic rabbits., The journal of sexual medicine, vol. 5 no. 9 (September, 2008), pp. 2069-78, ISSN 1743-6109 [doi]  [abs]
  3. CM Findley, RG Mitchell, BD Duscha, BH Annex, CD Kontos, Plasma levels of soluble Tie2 and vascular endothelial growth factor distinguish critical limb ischemia from intermittent claudication in patients with peripheral arterial disease., Journal of the American College of Cardiology, vol. 52 no. 5 (July, 2008), pp. 387-93, ISSN 1558-3597 [doi]  [abs]
  4. RR White, JA Roy, KD Viles, BA Sullenger, CD Kontos, A nuclease-resistant RNA aptamer specifically inhibits angiopoietin-1-mediated Tie2 activation and function., Angiogenesis, vol. 11 no. 4 (2008), pp. 395-401, ISSN 1573-7209 [doi]  [abs]
  5. CM Findley, MJ Cudmore, A Ahmed, CD Kontos, VEGF induces Tie2 shedding via a phosphoinositide 3-kinase/Akt dependent pathway to modulate Tie2 signaling., Arteriosclerosis, thrombosis, and vascular biology, vol. 27 no. 12 (December, 2007), pp. 2619-26, ISSN 1524-4636 [doi]  [abs]
  6. S Hazarika, AO Dokun, Y Li, AS Popel, CD Kontos, BH Annex, Impaired angiogenesis after hindlimb ischemia in type 2 diabetes mellitus: differential regulation of vascular endothelial growth factor receptor 1 and soluble vascular endothelial growth factor receptor 1., Circulation research, vol. 101 no. 9 (October, 2007), pp. 948-56, ISSN 1524-4571 [doi]  [abs]
  7. CD Kontos, BH Annex, Engineered transcription factors for therapeutic angiogenesis., Current opinion in molecular therapeutics, vol. 9 no. 2 (April, 2007), pp. 145-52, ISSN 1464-8431  [abs]
  8. Y Li, S Hazarika, D Xie, AM Pippen, CD Kontos, BH Annex, In mice with type 2 diabetes, a vascular endothelial growth factor (VEGF)-activating transcription factor modulates VEGF signaling and induces therapeutic angiogenesis after hindlimb ischemia., Diabetes, vol. 56 no. 3 (March, 2007), pp. 656-65, ISSN 0012-1797 [doi]  [abs]
  9. D Xie, Y Li, EA Reed, SI Odronic, CD Kontos, BH Annex, An engineered vascular endothelial growth factor-activating transcription factor induces therapeutic angiogenesis in ApoE knockout mice with hindlimb ischemia., Journal of vascular surgery, vol. 44 no. 1 (July, 2006), pp. 166-75, ISSN 0741-5214 [doi]  [abs]
  10. ES White, RG Atrasz, B Hu, SH Phan, V Stambolic, TW Mak, CM Hogaboam, KR Flaherty, FJ Martinez, CD Kontos, GB Toews, Negative regulation of myofibroblast differentiation by PTEN (Phosphatase and Tensin Homolog Deleted on chromosome 10)., American journal of respiratory and critical care medicine, vol. 173 no. 1 (January, 2006), pp. 112-21, ISSN 1073-449X [doi]  [abs]
  11. S Liu, RT Premont, CD Kontos, S Zhu, DC Rockey, A crucial role for GRK2 in regulation of endothelial cell nitric oxide synthase function in portal hypertension., Nature medicine, vol. 11 no. 9 (September, 2005), pp. 952-8, ISSN 1078-8956 [doi]  [abs]
  12. JA Hata, JA Petrofski, JN Schroder, ML Williams, SH Timberlake, A Pippen, MT Corwin, AK Solan, A Jakoi, TR Gehrig, CD Kontos, CA Milano, Modulation of phosphatidylinositol 3-kinase signaling reduces intimal hyperplasia in aortocoronary saphenous vein grafts., The Journal of thoracic and cardiovascular surgery, vol. 129 no. 6 (June, 2005), pp. 1405-13, ISSN 0022-5223 [doi]  [abs]
  13. J Huang, XL Niu, AM Pippen, BH Annex, CD Kontos, Adenovirus-mediated intraarterial delivery of PTEN inhibits neointimal hyperplasia., Arteriosclerosis, thrombosis, and vascular biology, vol. 25 no. 2 (February, 2005), pp. 354-8, ISSN 1524-4636 [doi]  [abs]
  14. Q Dai, J Huang, B Klitzman, C Dong, PJ Goldschmidt-Clermont, KL March, J Rokovich, B Johnstone, EJ Rebar, SK Spratt, CC Case, CD Kontos, BH Annex, Engineered zinc finger-activating vascular endothelial growth factor transcription factor plasmid DNA induces therapeutic angiogenesis in rabbits with hindlimb ischemia., Circulation, vol. 110 no. 16 (October, 2004), pp. 2467-75, ISSN 1524-4539 [doi]  [abs]
  15. KG Peters, CD Kontos, PC Lin, AL Wong, P Rao, L Huang, MW Dewhirst, S Sankar, Functional significance of Tie2 signaling in the adult vasculature., Recent progress in hormone research, vol. 59 (2004), pp. 51-71, ISSN 0079-9963  [abs]
  16. RR White, S Shan, CP Rusconi, G Shetty, MW Dewhirst, CD Kontos, BA Sullenger, Inhibition of rat corneal angiogenesis by a nuclease-resistant RNA aptamer specific for angiopoietin-2., Proceedings of the National Academy of Sciences of the United States of America, vol. 100 no. 9 (April, 2003), pp. 5028-33, ISSN 0027-8424 [doi]  [abs]
  17. XL Niu, KG Peters, CD Kontos, Deletion of the carboxyl terminus of Tie2 enhances kinase activity, signaling, and function. Evidence for an autoinhibitory mechanism., The Journal of biological chemistry, vol. 277 no. 35 (August, 2002), pp. 31768-73, ISSN 0021-9258 [doi]  [abs]
  18. J Huang, CD Kontos, PTEN modulates vascular endothelial growth factor-mediated signaling and angiogenic effects., The Journal of biological chemistry, vol. 277 no. 13 (March, 2002), pp. 10760-6, ISSN 0021-9258 [doi]  [abs]
  19. CD Kontos, EH Cha, JD York, KG Peters, The endothelial receptor tyrosine kinase Tie1 activates phosphatidylinositol 3-kinase and Akt to inhibit apoptosis., Molecular and cellular biology, vol. 22 no. 6 (March, 2002), pp. 1704-13, ISSN 0270-7306  [abs]
  20. CD Kontos, TP Stauffer, WP Yang, JD York, L Huang, MA Blanar, T Meyer, KG Peters, Tyrosine 1101 of Tie2 is the major site of association of p85 and is required for activation of phosphatidylinositol 3-kinase and Akt., Molecular and cellular biology, vol. 18 no. 7 (July, 1998), pp. 4131-40, ISSN 0270-7306  [abs]

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