Publications [#264417] of Sina Farsiu

Papers Published

1. Yanni, SE; Wang, J; Chan, M; Carroll, J; Farsiu, S; Leffler, JN; Spencer, R; Birch, EE, Foveal avascular zone and foveal pit formation after preterm birth., The British journal of ophthalmology, vol. 96 no. 7 (July, 2012), pp. 961-966 [22544530], [doi]
   (last updated on 2024/12/31)

   Abstract:
   

   Background

   Vascularisation of the macula takes place between 24 and 27 weeks post-conception. Preterm birth may affect the formation of the foveal avascular zone (FAZ) and foveal depression, and displacement of inner retinal layers away from the incipient fovea.

   Objective

   To examine whether vascular abnormalities accompany an inner retinal abnormality, and whether they are coincident.

   Methods

   High-density spectral domain optical coherence tomography volume scans were obtained from 24 preterm children and 34 full-term controls (5-16 years). Matlab programs were used to quantify total retinal thickness, thickness of individual retinal layers and metrics of foveal morphology. Summed voxel projections for the ganglion cell layer-inner nuclear layer were used to identify the FAZ.

   Results

   Preterm children had significantly smaller FAZ diameters than controls (p<0.0001). The foveal pits of preterm children were significantly shallower and less steep (p<0.0001) and total retinal thickness at the fovea was significantly increased (p<0.0001) compared to controls. The ganglion cell layer-inner plexiform layer and outer nuclear layer were significantly (p≤0.0001) thicker in preterm children than in controls.

   Conclusions

   Preterm birth results in abnormal foveal vascularisation, a failure of the inner retinal neurons to migrate away from the fovea, and an elevated outer nuclear layer ratio. The spatial coincidence of inner retinal and vascular abnormalities in preterm children supports the hypothesis that aspects of foveal development are interdependent.