Kathleen K. Smith, Professor
My current project focuses on the earliest patterning events. These projects include a study of heterochronies in the earliest morphological and genetic events in the head of marsupial and placental mammals, a study of neural crest in marupial mammals, and a study of patterns of Hox gene expression along the developing body axis, relations between the brain and cranial skeleton.
Ph.D., Harvard University, 1980
B.A., University of California at Santa Cruz, 1973
Office Location: 130 Science Drive, Room 122 Duke Box 90338, Durham, NC 27708
Office Phone: (919) 684-3402
Email Address: email@example.com
Web Page: http://www.biology.duke.edu/kksmithlab
Additional Web Page: http://www.biology.duke.edu/kksmithlab
Organismal Biology and Behavior
Research Categories: Functional morphology and evolution of vertebrates; craniofacial development, evolutionary morphology
Research Description: I am interested in the functional and evolutionary morphology of vertebrates. My research has included the functional and phylogenetic significance of variations in form of craniofacial structures in squamate reptiles and mammals, the biomechanics of a class of structures called musculohydrostats, and the roles of adaptive evolution and constraint in morphological diversification. My current focus is on the relation between evolutionary and developmental processes, with particular focus on the evolutionary, functional and developmental consequences of heterochronies in the morphogenesis of cranial nerves, muscles, bones and sensory structures in eutherian and metatherian mammals.
I have shown that one of the most fundamental differences between the two taxa is a delay in marsupials of the development of the central nervous system (CNS) and cranial sense organs and an advancement of certain cranial skeletal-muscular tissues. Specifically, in marsupials the central nervous system and particularly the forebrain is delayed relative to the development of the bones around the oral apparatus, the chondrocranium and the differentiation of cranial muscles. Currently my work is focused on the timing and pattern of early neural crest migration in marsupials. In recent years I have demonstrated that neural crest differentiates and migrates earlier in marsupials, relative to neural tube or somite differentiation, than in another other vertebrate thus far reported. I am now focusing on the patterns of expression of major genes thought to impose regional identity on the neural crest and neural tube.
In addition I am looking at the phylogenetic context of these heterochronies, with a comparative study of early development in therian mammals, monotremes, and non-mammalian amniotes in order to identify the primitive developmental condition for mammals.
- KN Adamski, AM Loyd, A Samost, B Myers, R Nightingale, K Smith and CR 'Dale' Bass, Pediatric Coronal Suture Fiber Alignment and the Effect of Interdigitation on Coronal Suture Mechanical Properties., Annals of biomedical engineering, vol. 43 no. 9 (September, 2015), pp. 2101-2111 [doi] [abs].
- KK Smith, Placental Evolution in Therian Mammals, in Great Transformations in Vertebrate Evolution, edited by KP Dial and N Shubin and EL Brainerd, manual (July, 2015), pp. 205-225, University of Chicago Press .
- AL Keyte and KK Smith, Heterochrony and developmental timing mechanisms: changing ontogenies in evolution., Seminars in cell & developmental biology, vol. 34 (October, 2014), pp. 99-107 [doi] [abs].
- AL Keyte and KK Smith, Heterochrony and developmental timing mechanisms: Changing ontogenies in evolution, Seminars in Cell and Developmental Biology, vol. 34 (January, 2014), pp. 99-107 [doi] [abs].
- K.K. Smith, THE PLACENTA IN THERIAN MAMMALS: NEW VIEWS ON THE MARSUPIAL PLACENTAL DICHOTOMY, in Great Transformations in Vertebrate Evolution., edited by Dial, Ken, Shubin, Neil, Brainerd, Elizabeth (2014), University of California Press (this was an invited chapter and was peer reviewed..) .