Mohamed A. Noor, Earl D. McLean Professor
Research in my laboratory strives to understand what genetic changes contribute to the formation of new species, and how the process of genetic recombination affects both species formation and molecular evolution. I've been fascinated at how often genetic recombination plays a major role in any evolutionary genetic question I seek to pursue, so understanding its causes and effects has become a thread uniting the dissertations of most people in the laboratory. Our approaches combine classical genetic, molecular genetic, and genomic/ bioinformatic analyses, along with occasional forays into areas like animal behavior (in relation to speciation). I am also very interested in helping develop educational activities (K-12 or college) in genetics and evolution. See my lab webpage for more detailed information: https://sites.google.com/site/noorlabduke/
Ph.D., University of Chicago, 1996
B.S., College of William and Mary, 1992
Research Categories: Speciation and evolutionary genetics, recombination
Research Description: One of the greatest unsolved questions in biology is how continuous processes of evolutionary change produce the discontinuous groups known as species. For a many years, my team studied hybrid sterility and behavioral mate preferences using classical, QTL-based, or molecular genetic approaches on Drosophila species as model organisms. More recently, the availability of multiple whole-genome sequences (some public but especially those we have obtained ourselves) has dramatically enhanced the scope of progress we make. A major question we've sought to address has been determining the genetic features and evolutionary processes that allow hybridizing species to persist, with particular interest in recombination and chromosomal inversions. In addition to questions in speciation, we are broadly interested in molecular evolution within species, again with a particular focus on the effects of recombination. See my lab web page for more information.
- CS Smukowski Heil, C Ellison, M Dubin and MAF Noor, Recombining without Hotspots: A Comprehensive Evolutionary Portrait of Recombination in Two Closely Related Species of Drosophila, Genome Biology and Evolution, vol. 7 no. 10 (October, 2015), pp. 2829-2842 [doi] .
- JN Gredler, AJ Hish and MA Noor, Temporal Stability of Molecular Diversity Measures in Natural Populations of Drosophila pseudoobscura and Drosophila persimilis., Journal of Heredity, vol. 106 no. 4 (July, 2015), pp. 407-411, Oxford University Press (OUP): Policy B - Oxford Open Option B [doi] [abs].
- KB Hoehn and MAF Noor, How Big Is Your Y? A Genome-Sequence Based Estimate of the Size of the Male-Specific Region in Megaselia scalaris, G3: Genes|Genomes|Genetics, vol. 5 no. 1 (January, 2015), pp. 45-48 [doi] .
- RB Myers, B Millman and MA Noor, Genetics and evolution: an iOS application to supplement introductory courses in transmission and evolutionary genetics., G3 (Bethesda, Md.), vol. 4 no. 5 (May, 2014), pp. 779-781 [doi] [abs].
- B Manzano-Winkler, SE McGaugh and MAF Noor, How Hot Are Drosophila Hotspots? Examining Recombination Rate Variation and Associations with Nucleotide Diversity, Divergence, and Maternal Age in Drosophila pseudoobscura, PLoS ONE, vol. 8 no. 8 (2013), pp. e71582 [doi] [abs].