Vikas Bhandawat, Assistant Professor  

Vikas Bhandawat

Education:
PhD, Johns Hopkins School of Medicine, 2005
M.S. in Chemistry, Indian Institute of Technology, 1999

Office Location: BioSci: 225
Office Phone: 919-684-1703
Email Address: bhandawat@gmail.com
Web Page: http://biology.duke.edu/bhandawatlab/

Specialties:
Neuroscience
Organismal Biology and Behavior

Research Categories: Drosophila olfaction

Research Description: THE GOAL: A major goal in neuroscience is to understand how neural circuits represent sensory information or guide behavior. Because of the complexity of our nervous system it is often difficult to pinpoint the neurons that participate in a given task. Our overall aim is to map out “complete circuits” underlying simple and complex behaviors and understand neural computations with a knowledge of this complete circuit in hand. APPROACH: We will focus on the relatively simple brain of Drosophila to attack this problem. The fly’s brain can perform a surprisingly diverse array of behaviors with relatively few neurons (~100000). In particular, the olfactory circuit of Drosophila is uniquely appropriate for studying this question because its anatomical organization makes it possible to quantify the pool of neurons activated by a given stimulus. This anatomical simplification occurs because for each odorant receptor gene (there are ~50 in flies), there is an identifiable first-order neuron and an identifiable second-order neuron.We have a nearly complete picture of odor representation at the level of olfactory receptor neurons (ORNs). Basic principles underlying the transformation of odor responses from ORNs-to-PNs are also understood. Because of this groundwork, odors (stimuli) can readily be mapped onto patterns of ORNs and PNs. TECHNIQUES: We use single-cell recordings from neurons in the fly brain to understand neural computations. We have also developed behavioral paradigms to make quantitative assessment of flies’ behavioral output. We will complement these relatively new techniques with molecular genetics in the fly.

Areas of Interest:
Neurobiology

Recent Publications   (More Publications)   (search)

  1. V Bhandawat, G Maimon, MH Dickinson, RI Wilson, Olfactory modulation of flight in Drosophila is sensitive, selective and rapid., The Journal of experimental biology, vol. 213 no. Pt 21 (November, 2010), pp. 3625-35 [doi]  [abs].
  2. V Bhandawat, J Reisert, KW Yau, Signaling by olfactory receptor neurons near threshold., Proceedings of the National Academy of Sciences of the United States of America, vol. 107 no. 43 (October, 2010), pp. 18682-7 [doi]  [abs].
  3. V Bhandawat, J Reisert, KW Yau, Signaling by olfactory receptor neurons near threshold., Proceedings of the National Academy of Sciences of the United States of America, vol. 107 no. 43 (October, 2010), pp. 18682-7 [doi]  [abs].
  4. SR Olsen*, V Bhandawat*, RI Wilson, Divisive normalization in olfactory population codes., Neuron, vol. 66 no. 2 (April, 2010), pp. 287-99 [doi]  [abs].
  5. JH Singer, E Glowatzki, T Moser, BW Strowbridge, V Bhandawat, AP Sampath, Functional properties of synaptic transmission in primary sense organs., The Journal of neuroscience : the official journal of the Society for Neuroscience, United States, vol. 29 no. 41 (October, 2009), pp. 12802-6  [abs].

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