Publications [#322975] of Sally A. Kornbluth
search PubMed.Papers Published
- Andersen, JL; Kornbluth, S, Mcl-1 rescues a glitch in the matrix.,
Nature cell biology, vol. 14 no. 6
(May, 2012),
pp. 563-565 [doi] .
(last updated on 2024/11/03)Abstract:
Bcl-2 family proteins are known to control cell death and influence mitochondrial function. The function of Mcl-1, an anti-apoptotic Bcl-2 protein, is now shown to depend on its subcellular localization. Mcl-1 at the mitochondrial outer membrane inhibits mitochondrial permeabilization to block apoptosis. However, a cleaved form of Mcl-1 localizes to the mitochondrial matrix and controls inner mitochondrial morphology and oxidative phosphorylation, without directly modulating apoptosis.