Publications [#323058] of Sally A. Kornbluth
search PubMed.Papers Published
- Evans, EK; Kornbluth, S, Regulation of apoptosis in Xenopus egg extracts.,
Advances in enzyme regulation, vol. 38 no. 1
(January, 1998),
pp. 265-280 [doi] .
(last updated on 2024/08/25)Abstract:
Although it is clear that caspase activation is an integral part of the apoptotic program, it is likely that caspases participate in the dismantling of the cell late in the apoptotic process. The upstream signaling events leading to caspase activation are only beginning to be elucidated. Although our data and that of others suggest that phosphotyrosine-mediated events participate in transmission of the apoptotic signal, it is not yet clear how these events are linked to caspase activation. Moreover, it remains to be determined whether tyrosine kinase pathways impinge upon apoptotic signaling in all tissues or are specific for certain cell types. The identification of crk as a key mediator of apoptotic signal transmission in the Xenopus egg extracts provides an excellent starting point to identify and characterize proteins which function in the induction of apoptosis. In particular, proteins interacting with the crk SH2 and crk SH3 domains are likely to be involved either upstream or downstream of crk in apoptotic signaling. Furthermore, the ability of bcr/abl to inhibit apoptosis in the egg extract should greatly facilitate the identification of abl substrates important for apoptotic inhibition.