Publications [#363972] of Lucia C. Strader
search PubMed.Papers Published
- Figueiredo, MRAD; Strader, LC, Intrinsic and extrinsic regulators of Aux/IAA protein degradation dynamics.,
Trends in biochemical sciences, vol. 47 no. 10
(October, 2022),
pp. 865-874, Elsevier BV [doi] .
(last updated on 2026/01/18)Abstract:
The plant hormone auxin acts through regulated degradation of Auxin/INDOLE-3-ACETIC ACID (Aux/IAA) proteins to regulate transcriptional events. In this review, we examine the composition and function of each Aux/IAA structural motif. We then focus on recent characterization of Aux/IAA N-terminal disordered regions, formation of secondary structure within these disordered regions, and post-translational modifications (PTMs) that affect Aux/IAA function and stability. We propose how structural variations between Aux/IAA family members may be tuned for differential transcriptional repression and degradation dynamics.