Zhen-Ming Pei, Associate Professor
My laboratory is interested in the early signaling events by which plants sense environmental signals and decode to give the appropriate responses. Upon perception of external signals, cell surface receptors trigger an increase in cytosolic free calcium concentration, which is mediated by ion channels. Our long-term goals are to identify these receptors and ion channels, isolate their interacting components, and assign molecular functions to them. Currently, we are using multidisciplinary approaches of biophysics, biochemistry, cell biology, molecular genetics, and function genomics to dissect the signaling cascades of external calcium as well as nitric oxide in the model plant Arabidopsis.
Education:
Ph.D., Shanghai Institute of Plant Physiology (China), 1993
M.S., Fudan University (China), 1990
B.S., Lanzhou University (China), 1985
Office Location: 3102 FFSC, Duke University, Durham, NC 27708-1000
Email Address: zpei@duke.edu
Specialties:
Cell and Molecular Biology
Genetics
Developmental Biology
Biophysics
Genomics
Research Categories: Plant Sensory Signal Transduction
Current projects: External calcium and nitric oxide signaling in Arabidopsis
Research Description: My laboratory is interested in the early signaling events by which plants sense environmental signals and decode to give the appropriate responses. Upon perception of external signals, cell surface receptors trigger an increase in cytosolic free calcium concentration, which is mediated by ion channels. Our long-term goals are to identify these receptors and ion channels, isolate their interacting components, and assign molecular functions to them. Currently, we are using multidisciplinary approaches of biophysics, biochemistry, cell biology, molecular genetics, and function genomics to dissect the signaling cascades of external calcium as well as nitric oxide in the model plant Arabidopsis.
Areas of Interest:
Calcium-mediated sensory process
Nitric oxide signaling
ABA signaling
Guard cell biology
Electrophysiology
Representative Publications (More Publications) (search)
- Tang, R-H; Han, S; Zheng, H; Cook, CW; Choi, CS; Woerner, TE; Jackson, RB; Pei, Z-M, Coupling diurnal cytosolic Ca2+ oscillations to the CAS-IP3 pathway in Arabidopsis., Science (New York, N.Y.), vol. 315 no. 5817 (March, 2007), pp. 1423-1426 [17347443], [doi] [abs].
- Pei, ZM; Kuchitsu, K, Early ABA signaling events in guard cells, Journal of Plant Growth Regulation, vol. 24 no. 4 (December, 2005), pp. 296-307, Springer Nature [pdf], [doi] [abs].
- He, Y; Tang, R-H; Hao, Y; Stevens, RD; Cook, CW; Ahn, SM; Jing, L; Yang, Z; Chen, L; Guo, F; Fiorani, F; Jackson, RB; Crawford, NM; Pei, Z-M, Nitric oxide represses the Arabidopsis floral transition., Science, vol. 305 no. 5692 (September, 2004), pp. 1968-1971 [15448272], [doi] [abs].
- Han, S; Tang, R; Anderson, LK; Woerner, TE; Pei, Z-M, A cell surface receptor mediates extracellular Ca(2+) sensing in guard cells., Nature, vol. 425 no. 6954 (September, 2003), pp. 196-200 [12968184], [doi] [abs].
- Pei, ZM; Murata, Y; Benning, G; Thomine, S; Klüsener, B; Allen, GJ; Grill, E; Schroeder, JI, Calcium channels activated by hydrogen peroxide mediate abscisic acid signalling in guard cells., Nature, vol. 406 no. 6797 (August, 2000), pp. 731-734 [pdf], [doi] [abs].
- Pei, ZM; Baizabal-Aguirre, VM; Allen, GJ; Schroeder, JI, A transient outward-rectifying K+ channel current down-regulated by cytosolic Ca2+ in Arabidopsis thaliana guard cells, Proceedings of the National Academy of Sciences of the United States of America, vol. 95 no. 11 (May, 1998), pp. 6548-6553, Proceedings of the National Academy of Sciences [pdf], [doi] [abs].
- Pei, ZM; Ghassemian, M; Kwak, CM; McCourt, P; Schroeder, JI, Role of farnesyltransferase in ABA regulation of guard cell anion channels and plant water loss., Science (New York, N.Y.), vol. 282 no. 5387 (October, 1998), pp. 287-290 [pdf], [doi] [abs].
- Pei, ZM; Kuchitsu, K; Ward, JM; Schwarz, M; Schroeder, JI, Differential abscisic acid regulation of guard cell slow anion channels in Arabidopsis wild-type and abi1 and abi2 mutants., The Plant cell, vol. 9 no. 3 (Spring, 1997), pp. 409-423 [pdf], [doi] [abs].
- Pei, ZM; Ward, JM; Harper, JF; Schroeder, JI, A novel chloride channel in Vicia faba guard cell vacuoles activated by the serine/threonine kinase, CDPK., The EMBO journal, vol. 15 no. 23 (December, 1996), pp. 6564-6574 [picrender.fcgi], [doi] [abs].