Publications of Amanda Hargrove


  1. Hargrove, AE, "Preface"January,, 2019, 623, xv-xvii [doi].

Journal Articles

  1. Zafferani, M; Hargrove, AE, "Small molecule targeting of biologically relevant RNA tertiary and quaternary structures.", Cell Chemical BiologyMay,, 2021, 28(5), 594-609, Elsevier BV [doi[abs].

  2. Falese, JP; Donlic, A; Hargrove, AE, "Targeting RNA with small molecules: from fundamental principles towards the clinic.", Chem. Soc. Rev.March,, 2021, 50(4), 2224-2243 [doi[abs].

  3. Umuhire Juru, A; Hargrove, AE, "Frameworks for targeting RNA with small molecules.", The Journal of Biological ChemistryDecember,, 2020 [doi[abs].

  4. Zafferani, M; Haddad, C; Luo, L; Davila-Calderon, J; Yuan-Chiu, L; Shema Mugisha, C; Monaghan, AG; Kennedy, AA; Yesselman, JD; Gifford, RR; Tai, AW; Kutluay, SB; Li, M-L; Brewer, G; Tolbert, BS; Hargrove, AE, "Amilorides inhibit SARS-CoV-2 replication in vitro by targeting RNA structures.", BiorxivDecember,, 2020 [doi[abs].

  5. Hargrove, AE, "Small molecule-RNA targeting: starting with the fundamentals.", Chemical CommunicationsNovember,, 2020, 56(94), 14744-14756 [doi[abs].

  6. Davila-Calderon, J; Patwardhan, NN; Chiu, L-Y; Sugarman, A; Cai, Z; Penutmutchu, SR; Li, M-L; Brewer, G; Hargrove, AE; Tolbert, BS, "IRES-targeting small molecule inhibits enterovirus 71 replication via allosteric stabilization of a ternary complex.", Nature CommunicationsSeptember,, 2020, 11(1), 4775, Springer Science and Business Media LLC [doi[abs].

  7. Donlic, A; Zafferani, M; Padroni, G; Puri, M; Hargrove, AE, "Regulation of MALAT1 triple helix stability and in vitro degradation by diphenylfurans.", Nucleic Acids ResearchAugust,, 2020, 48(14), 7653-7664 [doi[abs].

  8. Padroni, G; Patwardhan, NN; Schapira, M; Hargrove, AE, "Systematic analysis of the interactions driving small molecule-RNA recognition.", Rsc Medicinal ChemistryJuly,, 2020, 11(7), 802-813 [doi[abs].

  9. Umuhire Juru, A; Cai, Z; Jan, A; Hargrove, AE, "Template-guided selection of RNA ligands using imine-based dynamic combinatorial chemistry.", Chemical CommunicationsMarch,, 2020, 56(24), 3555-3558 [doi[abs].

  10. Ganser, LR; Kelly, ML; Patwardhan, NN; Hargrove, AE; Al-Hashimi, HM, "Demonstration that Small Molecules can Bind and Stabilize Low-abundance Short-lived RNA Excited Conformational States.", J Mol BiolFebruary,, 2020, 432(4), 1297-1304 [doi[abs].

  11. Hargrove, AE, "The next 20 years of Medicinal Research Reviews.", Medicinal Research ReviewsJanuary,, 2020, 40(1), 7-8 [doi].

  12. Morgan, BS; Sanaba, BG; Donlic, A; Karloff, DB; Forte, JE; Zhang, Y; Hargrove, AE, "R-BIND: An Interactive Database for Exploring and Developing RNA-Targeted Chemical Probes.", Acs Chemical BiologyDecember,, 2019, 14(12), 2691-2700 [doi[abs].

  13. Patwardhan, NN; Cai, Z; Umuhire Juru, A; Hargrove, AE, "Driving factors in amiloride recognition of HIV RNA targets.", Organic & Biomolecular ChemistryOctober,, 2019, 17(42), 9313-9320 [doi[abs].

  14. Wicks, SL; Hargrove, AE, "Fluorescent indicator displacement assays to identify and characterize small molecule interactions with RNA.", Methods (San Diego, Calif.)September,, 2019, 167, 3-14 [doi[abs].

  15. Umuhire Juru, A; Patwardhan, NN; Hargrove, AE, "Understanding the Contributions of Conformational Changes, Thermodynamics, and Kinetics of RNA-Small Molecule Interactions.", Acs Chemical BiologyMay,, 2019, 14(5), 824-838 [doi[abs].

  16. Donlic, A; Morgan, BS; Xu, JL; Liu, A; Roble, C; Hargrove, AE, "Corrigendum: Discovery of Small Molecule Ligands for MALAT1 by Tuning an RNA-Binding Scaffold.", Angewandte Chemie International EditionApril,, 2019, 58(17), 5482 [doi[abs].

  17. Eubanks, CS; Zhao, B; Patwardhan, NN; Thompson, RD; Zhang, Q; Hargrove, AE, "Visualizing RNA Conformational Changes via Pattern Recognition of RNA by Small Molecules.", Journal of the American Chemical SocietyApril,, 2019, 141(14), 5692-5698 [doi[abs].

  18. Patwardhan, NN; Cai, Z; Newson, CN; Hargrove, AE, "Fluorescent peptide displacement as a general assay for screening small molecule libraries against RNA.", Organic & Biomolecular ChemistryFebruary,, 2019, 17(7), 1778-1786 [doi[abs].

  19. Eubanks, CS; Hargrove, AE, "RNA Structural Differentiation: Opportunities with Pattern Recognition.", BiochemistryJanuary,, 2019, 58(4), 199-213 [doi[abs].

  20. Donlic, A; Morgan, BS; Xu, JL; Liu, A; Roble, C; Hargrove, AE, "Discovery of Small Molecule Ligands for MALAT1 by Tuning an RNA-Binding Scaffold.", Angewandte Chemie International EditionOctober,, 2018, 57(40), 13242-13247 [doi[abs].

  21. Morgan, BS; Forte, JE; Hargrove, AE, "Insights into the development of chemical probes for RNA.", Nucleic Acids ResearchSeptember,, 2018, 46(16), 8025-8037 [doi[abs].

  22. Donlic, A; Hargrove, AE, "Targeting RNA in mammalian systems with small molecules.", Wiley Interdisciplinary Reviews. RnaJuly,, 2018, 9(4), e1477 [doi[abs].

  23. Eubanks, CS; Hargrove, AE, "Sensing the impact of environment on small molecule differentiation of RNA sequences.", Chemical CommunicationsDecember,, 2017, 53(100), 13363-13366 [doi[abs].

  24. Morgan, BS; Forte, JE; Culver, RN; Zhang, Y; Hargrove, AE, "Discovery of Key Physicochemical, Structural, and Spatial Properties of RNA-Targeted Bioactive Ligands.", Angewandte Chemie International EditionOctober,, 2017, 56(43), 13498-13502 [doi[abs].

  25. Patwardhan, NN; Ganser, LR; Kapral, GJ; Eubanks, CS; Lee, J; Sathyamoorthy, B; Al-Hashimi, HM; Hargrove, AE, "Amiloride as a new RNA-binding scaffold with activity against HIV-1 TAR.", MedchemcommMay,, 2017, 8(5), 1022-1036 [doi[abs].

  26. Eubanks, CS; Forte, JE; Kapral, GJ; Hargrove, AE, "Small Molecule-Based Pattern Recognition To Classify RNA Structure.", Journal of the American Chemical SocietyJanuary,, 2017, 139(1), 409-416 [doi[abs].

  27. McFadden, EJ; Hargrove, AE, "Biochemical Methods To Investigate lncRNA and the Influence of lncRNA:Protein Complexes on Chromatin.", BiochemistryMarch,, 2016, 55(11), 1615-1630 [doi[abs].

  28. Burg, JM; Link, JE; Morgan, BS; Heller, FJ; Hargrove, AE; McCafferty, DG, "KDM1 class flavin-dependent protein lysine demethylases.", BiopolymersJuly,, 2015, 104(4), 213-246 [doi[abs].

  29. Hargrove, AE; Martinez, TF; Hare, AA; Kurmis, AA; Phillips, JW; Sud, S; Pienta, KJ; Dervan, PB, "Tumor Repression of VCaP Xenografts by a Pyrrole-Imidazole Polyamide.", edited by Agoulnik, IU , Plos OneJanuary,, 2015, 10(11), e0143161 [doi[abs].

  30. Morgan, BS; Hargrove, AE, "Synthetic receptors for oligonucleotides and nucleic acids", Monographs in Supramolecular ChemistryJanuary,, 2015, 2015-January(14), 253-325.

  31. Nickols, NG; Szablowski, JO; Hargrove, AE; Li, BC; Raskatov, JA; Dervan, PB, "Activity of a Py-Im polyamide targeted to the estrogen response element.", Molecular Cancer TherapeuticsMay,, 2013, 12(5), 675-684 [doi[abs].

  32. Raskatov, JA; Nickols, NG; Hargrove, AE; Marinov, GK; Wold, B; Dervan, PB, "Gene expression changes in a tumor xenograft by a pyrrole-imidazole polyamide.", Proceedings of the National Academy of Sciences of the United States of AmericaOctober,, 2012, 109(40), 16041-16045 [doi[abs].

  33. Hargrove, AE; Raskatov, JA; Meier, JL; Montgomery, DC; Dervan, PB, "Characterization and solubilization of pyrrole-imidazole polyamide aggregates.", Journal of Medicinal ChemistryJune,, 2012, 55(11), 5425-5432 [doi[abs].

  34. Raskatov, JA; Hargrove, AE; So, AY; Dervan, PB, "Pharmacokinetics of Py-Im polyamides depend on architecture: cyclic versus linear.", Journal of the American Chemical SocietyMay,, 2012, 134(18), 7995-7999 [doi[abs].

  35. Hargrove, AE; Nieto, S; Zhang, T; Sessler, JL; Anslyn, EV, "Artificial receptors for the recognition of phosphorylated molecules.", Chemical ReviewsNovember,, 2011, 111(11), 6603-6782 [doi].

  36. Hargrove, AE; Ellington, AD; Anslyn, EV; Sessler, JL, "Chemical functionalization of oligodeoxynucleotides with multiple boronic acids for the polyvalent binding of saccharides.", Bioconjugate ChemistryMarch,, 2011, 22(3), 388-396 [doi[abs].

  37. Hargrove, AE; Reyes, RN; Riddington, I; Anslyn, EV; Sessler, JL, "Boronic acid porphyrin receptor for ginsenoside sensing.", Organic LettersNovember,, 2010, 12(21), 4804-4807 [doi[abs].

  38. Hargrove, AE; Zhong, Z; Sessler, JL; Anslyn, EV, "Algorithms for the determination of binding constants and enantiomeric excess in complex host: Guest equilibria using optical measurements", New Journal of ChemistryJanuary,, 2010, 34(2), 348-354, Royal Society of Chemistry (RSC) [doi[abs].

  39. Collins, BE; Sorey, S; Hargrove, AE; Shabbir, SH; Lynch, VM; Anslyn, EV, "Probing intramolecular B-N interactions in ortho-aminomethyl arylboronic acids", The Journal of Organic ChemistryJune,, 2009, 74(11), 4055-4060, American Chemical Society (ACS) [doi[abs].

  40. Pikulski, M; Hargrove, A; Shabbir, SH; Anslyn, EV; Brodbelt, JS, "Sequencing and characterization of oligosaccharides using infrared multiphoton dissociation and boronic acid derivatization in a quadrupole ion trap.", Journal of the American Society for Mass SpectrometryDecember,, 2007, 18(12), 2094-2106 [doi[abs].

  41. Spence, JD; Hargrove, AE; Crampton, HL; Thomas, DW, "Porphyrenediynes: synthesis and cyclization of meso-enediynylporphyrins", Tetrahedron LettersJanuary,, 2007, 48(4), 725-728, Elsevier BV [doi[abs].

  42. Sessler, JL; Lee, JT; Ou, Z; Köhler, T; Hargrove, AE; Cho, WS; Lynch, V; Kadish, KM, "Chemical and electrochemical oxidation of N-alkyl cyclo[n]-pyrroles", Journal of Porphyrins and PhthalocyaninesJanuary,, 2006, 10(12), 1329-1336, World Scientific Pub Co Pte Lt [doi[abs].

Chapter in Book

  1. Padroni, G; Eubanks, CS; Hargrove, AE, "Differentiation and classification of RNA motifs using small molecule-based pattern recognition.", in Methods in EnzymologyJanuary,, 2019, 623, 101-130 [doi[abs].

  2. Hargrove, AE, "RNA Recognition", in RNA RECOGNITION, edited by Hargrove, AE January,, 2019, 623, XV-XVII, ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD.

  3. Hargrove, AE, "Preface.", 2019, 623, xv-xvii [doi].