Publications [#231791] of Steven W. Baldwin

Journal Articles

1. Adler, MJ; Baldwin, SW, Direct, regioselective synthesis of 2,2-dimethyl-2H-chromenes. Total syntheses of octandrenolone and precocenes I and II, Tetrahedron Letters, vol. 50 no. 36 (September, 2009), pp. 5075-5079, Elsevier BV, ISSN 0040-4039 [doi]
   (last updated on 2026/01/21)

   Abstract:
   Herein is reported an efficient method for the synthesis of 2,2-dimethyl-2H-chromenes in a single step from the corresponding phenol and 3-methyl-2-butenal via microwave irradiation in CDCl3. This protocol features a mild reaction environment (neutral, no added catalyst) which yields regioselective formation of the chromene and displays tolerance toward acid- and base-sensitive protecting groups. © 2009 Elsevier Ltd. All rights reserved.