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Research Interests for Steven W. Baldwin

Research Interests: chemistry

The central themes of our research program are the development of methodology to accomplish the synthesis of optically pure materials and the subsequent application of the new methodology to the total synthesis of biologically significant natural products. At the present time there are several different approaches to a variety of targets in progress in our laboratories. The first is the transfer of chirality from optically active hydroxylamines (e.g.,1) employing intra-and intermolecular nitrone /alkene cycloaddition reactions in the chirality transfer step. Particular targets for this chemistry are several ''unusual'' alpha-amino acids (2) as well as alkaloids related to pretazettine (3). The synthesis of pretazettine is also being addressed in a different approach involving a chiral ring expansion of allylic alcohol (4). Recently, significant progress has been realized in the synthesis the alkaloid gelsemicine (7) based on the Diels-Alder reaction of chiral maleimides such as (5). It has been found, for instance, that diastereomeric ratios in excess of 50/1 can be realized when (5) is allowed to react with silicon substituted butadiene (6) in a Lewis-acid catalyzed reaction.

Recent Publications
  1. Baldwin, SM; Bercaw, JE; Henling, LM; Day, MW; Brintzinger, HH, Cationic alkylaluminum-complexed zirconocene hydrides: NMR-spectroscopic identification, crystallographic structure determination, and interconversion with other zirconocene cations, Journal of the American Chemical Society, vol. 133 no. 6 (2011), pp. 1805-1813, American Chemical Society (ACS), ISSN 0002-7863 [doi[abs]
  2. Baldwin, SM; Bercaw, JE; Brintzinger, HH, Cationic alkylaluminum-complexed zirconocene hydrides as participants in olefin polymerization catalysis, Journal of the American Chemical Society, vol. 132 no. 40 (October, 2010), pp. 13969-13971, American Chemical Society (ACS), ISSN 0002-7863 [doi[abs]
  3. Adler, MJ; Baldwin, SW, Direct, regioselective synthesis of 2,2-dimethyl-2H-chromenes. Total syntheses of octandrenolone and precocenes I and II, Tetrahedron Letters, vol. 50 no. 36 (September, 2009), pp. 5075-5079, Elsevier BV, ISSN 0040-4039 [doi[abs]
  4. Baldwin, SM; Bereaw, JE; Brintzinger, HH, Alkylaluminum-complexed zirconocene hydrides: Identification of hydride-bridged species by NMR spectroscopy, Journal of the American Chemical Society, vol. 130 no. 51 (December, 2008), pp. 17423-17433, American Chemical Society (ACS), ISSN 0002-7863 [doi[abs]
  5. Mao, Z; Baldwin, SW, New spirocyclic oxindole synthesis based on a hetero Claisen rearrangement., Organic letters, vol. 6 no. 14 (July, 2004), pp. 2425-2428, ISSN 1523-7060 [15228295], [doi[abs]

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