Publications [#231797] of Steven W. Baldwin

Journal Articles

1. Mao, Z; Baldwin, SW, New spirocyclic oxindole synthesis based on a hetero Claisen rearrangement., Organic letters, vol. 6 no. 14 (July, 2004), pp. 2425-2428, ISSN 1523-7060 [15228295], [doi]
   (last updated on 2026/01/22)

   Abstract:
   [reaction: see text] A new method for preparing spirocyclic oxindoles is presented. Featuring a [3,3]-sigmatropic enolate rearrangement, the three-step process converts carboxylic acid starting materials to oxidnole products in overall yields of 52-76%. The enolate rearrangement step occurs at -78 degrees C and provides easy access to oxindole products that have previously been difficult to prepare.