Publications [#80087] of Christopher D. Kontos

Papers Published

1. KG Peters, A Coogan, D Berry, J Marks, JD Iglehart, CD Kontos, P Rao, S Sankar, E Trogan, Expression of Tie2/Tek in breast tumour vasculature provides a new marker for evaluation of tumour angiogenesis., British journal of cancer, SCOTLAND, vol. 77 no. 1 (1998), pp. 51-6, ISSN 0007-0920
   (last updated on 2007/12/01)

   Abstract:
   Endothelial receptor tyrosine kinases may play important roles in pathological vascular growth, particularly in tumours. In this study, immunohistochemistry was used to evaluate the expression of a novel endothelial receptor tyrosine kinase, Tie2/Tek, in the endothelium of vascular 'hotspots' in normal breast tissue (n = 10), benign breast lesions (n = 10) and in breast tumours (n = 123). Tie2 expression was detected in the endothelium of all breast tissues examined. However, the strongest expression of Tie-2 was seen in vascular 'hot spots' within the inflammatory infiltrate at the periphery of invasive tumours. Moreover, the proportion of Tie2-positive vessels (Tie2 counts/CD31 counts) was significantly higher in breast tumours than the proportion of Tie2-positive vessels in either normal breast tissue or benign breast lesions (P = 0.004 and 0.0001 respectively). These data are consistent with a role for Tie2 in tumour angiogenesis and demonstrate the potential use of Tie2 expression as a novel marker of the tumour vasculature.

   Keywords:
   Antibodies, Monoclonal • Breast • Breast Neoplasms • Endothelium, Vascular • Female • Humans • Immunohistochemistry • Neovascularization, Pathologic • Receptor Protein-Tyrosine Kinases • Receptor, TIE-2 • Tumor Markers, Biological • blood • blood supply* • enzymology • enzymology* • metabolism*