L. Ryan Baugh, Professor  

L. Ryan Baugh

The Baugh Lab is interested in phenotypic plasticity and adaptation to starvation. We use the roundworm C. elegans for an integrative organismal approach that considers molecular mechanisms in a developmental and ecological context. We are studying how development is governed by nutrient availability, how animals survive starvation, long-term consequences of early life starvation, and multigenerational plasticity.

Education:
Ph.D., Harvard University, 2004
B.S., University of Georgia, 1997

Office Location: 4314 French Family Science Center, Duke Box 90338, Durham, NC 27708
Email Address: ryan.baugh@duke.edu
Web Page: https://baughlab.biology.duke.edu/

Specialties:
Developmental Biology
Cell and Molecular Biology
Genomics
Genetics

Research Categories: Developmental genetics and genomics

Research Description: We study nutritional control of development in the roundworm Caenorhabditis elegans. We are interested in the signaling networks and gene regulatory mechanisms that support phenotypic plasticity enablng worms to thrive in fluctuating environmental conditions.

Areas of Interest:
nutritional control of development
gene regulation
insulin signaling
aging

Representative Publications   (More Publications)   (search)

  1. Y Chen, LR Baugh, Ins-4 and daf-28 function redundantly to regulate C. elegans L1 arrest., Developmental Biology (August, 2014) [002], [doi]  [abs].
  2. Schindler, AJ; Baugh, LR; Sherwood, DR, Identification of late larval stage developmental checkpoints in Caenorhabditis elegans regulated by insulin/IGF and steroid hormone signaling pathways., PLoS genetics, vol. 10 no. 6 (June, 2014), pp. e1004426 [repository], [doi]  [abs].
  3. Maxwell, CS; Kruesi, WS; Core, LJ; Kurhanewicz, N; Waters, CT; Lewarch, CL; Antoshechkin, I; Lis, JT; Meyer, BJ; Baugh, LR, Pol II docking and pausing at growth and stress genes in C. elegans., Cell reports, vol. 6 no. 3 (February, 2014), pp. 455-466 [repository], [doi]  [abs].
  4. Baugh, LR, To grow or not to grow: nutritional control of development during Caenorhabditis elegans L1 arrest., Genetics, vol. 194 no. 3 (July, 2013), pp. 539-555 [23824969], [doi]  [abs] [author's comments].
  5. Moore, BT; Jordan, JM; Baugh, LR, WormSizer: high-throughput analysis of nematode size and shape., PloS one, vol. 8 no. 2 (January, 2013), pp. e57142 [23451165], [doi]  [abs].
  6. Maxwell, CS; Antoshechkin, I; Kurhanewicz, N; Belsky, JA; Baugh, LR, Nutritional control of mRNA isoform expression during developmental arrest and recovery in C. elegans., Genome research, vol. 22 no. 10 (October, 2012), pp. 1920-1929 [22539650], [doi]  [abs].
  7. Zaslaver, A; Baugh, LR; Sternberg, PW, Metazoan operons accelerate recovery from growth-arrested states., Cell, vol. 145 no. 6 (June, 2011), pp. 981-992 [repository], [doi]  [abs].
  8. Baugh, LR; Kurhanewicz, N; Sternberg, PW, Sensitive and precise quantification of insulin-like mRNA expression in Caenorhabditis elegans., PloS one, vol. 6 no. 3 (March, 2011), pp. e18086 [21445366], [doi]  [abs].
  9. Baugh, LR; Demodena, J; Sternberg, PW, RNA Pol II accumulates at promoters of growth genes during developmental arrest., Science (New York, N.Y.), vol. 324 no. 5923 (April, 2009), pp. 92-94 [1169628], [doi]  [abs].
  10. Baugh, LR; Sternberg, PW, DAF-16/FOXO regulates transcription of cki-1/Cip/Kip and repression of lin-4 during C. elegans L1 arrest., Current biology : CB, vol. 16 no. 8 (April, 2006), pp. 780-785 [doi]  [abs].