Publications of Qiu Wang

Papers Submitted

  1. McDonald, S. L.; Hendrick, C. E.; Wang, Q., "Copper-Catalyzed Amination of Arenes and Heteroarenes via Zn(tmp)2-Mediated Metalation", 2013.

  2. Feng, Y.; Sokol, E.; Del Vecchio, C.; Sanduja, S.; Claessen, J.; Proia, T.; Jin, D.; Reinhardt, F.; Ploegh, H.L.; Wang, Q.; Gupta, P, "Epithelial-to-Mesenchymal Transition Sensitizes Cells to Endoplasmic Reticulum Stress and Activates PERK-eIF2α Signaling", 2013.

  3. Ortiz, Jr. G. X.; Kang, B.;§ Wang, Q., "A Rapid and Efficient Approach to 3-Azido- and 3-Aminopiperidines by Intramolecular Cyclization of Unsaturated Amines", 2013.

Journal Articles

  1. Devaraj, N; Fox, JM; Lei, X; Wang, Q, "Next-Generation Organic Chemistry for Labeling and Imaging.", The Journal of organic chemistryOctober,, 2024, 89(20), 14609-14611 [doi].

  2. Nguyen, AL; Zhang, J; Huang, S-H; Wang, Q, "Copper-Catalyzed 1,3-Aminocyclization of Cyclopropanes as a Rapid Entry to γ-Amino Heterocycles.", Organic lettersOctober,, 2024 [doi] [abs].

  3. Feng, G; Wang, Q, "Enantioselective synthesis of axially chiral P-containing allenes for allenyl chirality", Chem CatalysisMarch,, 2024, 4(3) [doi] [abs].

  4. Zhuang, L; Wang, Q; Lei, A; Zhou, Q, "Celebrating the 130th anniversary of Wuhan University.", Chemical scienceFebruary,, 2024, 15(6), 1921-1923 [doi] [abs].

  5. Watkins, NH; Kwon, Y; Wang, Q, "Copper-catalyzed 1,4-aminohydroxylation and aminothiolation of 1,3-dienes by carbonyl-assisted migration", Chem CatalysisJanuary,, 2024 [doi] [abs].

  6. Feng, G; Ku, CK; Zhao, J; Wang, Q, "Copper-Catalyzed Three-Component Aminofluorination of Alkenes and 1,3-Dienes: Direct Entry to Diverse β-Fluoroalkylamines.", Journal of the American Chemical SocietyNovember,, 2022, 144(44), 20463-20471 [doi] [abs].

  7. Park, H; Eriksson, S; Warren, WS; Wang, Q, "Design, synthesis and evaluation of 15N- and 13C-labeled molecular probes as hyperpolarized nitric oxide sensors.", Bioorganic & medicinal chemistryOctober,, 2022, 72, 116969 [doi] [abs].

  8. Park, H; Chen, J; Dimitrov, IE; Park, JM; Wang, Q, "Design and Characterization of Hyperpolarized 15N-BBCP as a H2O2-Sensing Probe.", ACS sensorsOctober,, 2022, 7(10), 2928-2933 [doi] [abs].

  9. Kwon, Y; Wang, Q, "Recent Advances in 1,2-Amino(hetero)arylation of Alkenes.", Chemistry, an Asian journalJune,, 2022, 17(12), e202200215 [doi] [abs].

  10. Park, H; Wang, Q, "State-of-the-art accounts of hyperpolarized 15N-labeled molecular imaging probes for magnetic resonance spectroscopy and imaging.", Chemical scienceJune,, 2022, 13(25), 7378-7391 [doi] [abs].

  11. Cho, S; McLaren, EJ; Wang, Q, "Three-Component Difunctionalization of Cyclohexenyl Triflates: Direct Access to Versatile Cyclohexenes via Cyclohexynes.", Angewandte Chemie (International ed. in English)December,, 2021, 60(50), 26332-26336 [doi] [abs].

  12. Bae, J; Zhang, G; Park, H; Warren, WS; Wang, Q, "15N-Azides as practical and effective tags for developing long-lived hyperpolarized agents.", Chemical scienceNovember,, 2021, 12(42), 14309-14315 [doi] [abs].

  13. Kwon, Y; Zhang, W; Wang, Q, "Copper-Catalyzed Aminoheteroarylation of Unactivated Alkenes through Distal Heteroaryl Migration.", ACS catalysisJuly,, 2021, 11(14), 8807-8817 [doi] [abs].

  14. Wang, L; Wang, H; Shen, K; Park, H; Zhang, T; Wu, X; Hu, M; Yuan, H; Chen, Y; Wu, Z; Wang, Q; Li, Z, "Development of Novel 18F-PET Agents for Tumor Hypoxia Imaging.", Journal of medicinal chemistryMay,, 2021, 64(9), 5593-5602 [doi] [abs].

  15. Zhang, W; Wang, C; Wang, Q, "Copper-Catalyzed Decarboxylative Functionalization of Conjugated β,γ-Unsaturated Carboxylic Acids.", ACS catalysisNovember,, 2020, 10(22), 13179-13185 [doi] [abs].

  16. Kwon, Y; Wang, Q, "Copper-Catalyzed 1,2-Aminocyanation of Unactivated Alkenes via Cyano Migration.", Organic lettersJune,, 2020, 22(11), 4141-4145 [doi] [abs].

  17. Park, H; Zhang, G; Bae, J; Theis, T; Warren, WS; Wang, Q, "Application of 15N2-Diazirines as a Versatile Platform for Hyperpolarization of Biological Molecules by d-DNP.", Bioconjugate chemistryMarch,, 2020, 31(3), 537-541 [doi] [abs].

  18. Park, H; Urs, AN; Zimmerman, J; Liu, C; Wang, Q; Urs, NM, "Structure-Functional-Selectivity Relationship Studies of Novel Apomorphine Analogs to Develop D1R/D2R Biased Ligands.", ACS medicinal chemistry lettersMarch,, 2020, 11(3), 385-392 [doi] [abs].

  19. Cho, S; Wang, Q, "1,2-Difunctionalization of Aryl Triflates: A Direct and Modular Access to Diversely Functionalized Anilines.", Organic lettersFebruary,, 2020, 22(4), 1670-1674 [doi] [abs].

  20. Hemric, BN; Chen, AW; Wang, Q, "Copper-Catalyzed 1,2-Amino Oxygenation of 1,3-Dienes: A Chemo-, Regio-, and Site-Selective Three-Component Reaction with O-Acylhydroxylamines and Carboxylic Acids.", ACS catalysisNovember,, 2019, 9(11), 10070-10076 [doi] [abs].

  21. Hemric, BN; Chen, AW; Wang, Q, "Copper-Catalyzed Modular Amino Oxygenation of Alkenes: Access to Diverse 1,2-Amino Oxygen-Containing Skeletons.", The Journal of organic chemistryFebruary,, 2019, 84(3), 1468-1488 [doi] [abs].

  22. Cho, S; Wang, Q, "ortho-Difunctionalization of arynes by LiZnEt2(TMP)-mediated deprotonative zincation/elimination of aryl triflates", TetrahedronJune,, 2018, 74(26), 3325-3328, Elsevier BV [doi] [abs].

  23. Liu, C; Wang, Q, "Alkenylation of C(sp3 )-H Bonds by Zincation/Copper-Catalyzed Cross-Coupling with Iodonium Salts.", Angewandte Chemie (International ed. in English)April,, 2018, 57(17), 4727-4731 [doi] [abs].

  24. Bae, J; Zhou, Z; Theis, T; Warren, WS; Wang, Q, "15N4-1,2,4,5-tetrazines as potential molecular tags: Integrating bioorthogonal chemistry with hyperpolarization and unearthing para-N2.", Science advancesMarch,, 2018, 4(3), eaar2978 [doi] [abs].

  25. Ortiz, GX; Chansaenpak, K; Wang, M; Ma, X; Wang, H; Li, Z; Wang, Q, "A Novel 18 F-Labeling Method for the Synthesis of [ 18 F]-Piperidine-Containing Ligands as Potential PET Radiotracers for σ Receptors", SynlettMarch,, 2018, 29(4), 410-414, Georg Thieme Verlag KG [doi] [abs].

  26. Shen, K; Wang, Q, "Copper-catalyzed aminoalkynylation of alkenes with hypervalent iodine reagents.", Chemical scienceDecember,, 2017, 8(12), 8265-8270 [doi] [abs].

  27. Shen, K; Logan, AWJ; Colell, JFP; Bae, J; Ortiz, GX; Theis, T; Warren, WS; Malcolmson, SJ; Wang, Q, "Titelbild: Diazirines as Potential Molecular Imaging Tags: Probing the Requirements for Efficient and Long‐Lived SABRE‐Induced Hyperpolarization (Angew. Chem. 40/2017)", Angewandte ChemieSeptember,, 2017, 129(40), 12179-12179, Wiley [doi].

  28. Shen, K; Logan, AWJ; Colell, JFP; Bae, J; Ortiz, GX; Theis, T; Warren, WS; Malcolmson, SJ; Wang, Q, "Cover Picture: Diazirines as Potential Molecular Imaging Tags: Probing the Requirements for Efficient and Long‐Lived SABRE‐Induced Hyperpolarization (Angew. Chem. Int. Ed. 40/2017)", Angewandte Chemie International EditionSeptember,, 2017, 56(40), 12015-12015, Wiley [doi].

  29. Shen, K; Logan, AWJ; Colell, JFP; Bae, J; Ortiz, GX; Theis, T; Warren, WS; Malcolmson, SJ; Wang, Q, "Diazirines as Potential Molecular Imaging Tags: Probing the Requirements for Efficient and Long‐Lived SABRE‐Induced Hyperpolarization", Angewandte ChemieSeptember,, 2017, 129(40), 12280-12284, Wiley [doi] [abs].

  30. Shen, K; Wang, Q, "Copper-Catalyzed Alkene Aminoazidation as a Rapid Entry to 1,2-Diamines and Installation of an Azide Reporter onto Azahetereocycles.", Journal of the American Chemical SocietySeptember,, 2017, 139(37), 13110-13116 [doi] [abs].

  31. Shen, K; Logan, AWJ; Colell, JFP; Bae, J; Ortiz, GX; Theis, T; Warren, WS; Malcolmson, SJ; Wang, Q, "Diazirines as Potential Molecular Imaging Tags: Probing the Requirements for Efficient and Long-Lived SABRE-Induced Hyperpolarization.", Angewandte Chemie (International ed. in English)September,, 2017, 56(40), 12112-12116 [doi] [abs].

  32. Hendrick, CE; Bitting, KJ; Cho, S; Wang, Q, "Site-Selective Copper-Catalyzed Amination and Azidation of Arenes and Heteroarenes via Deprotonative Zincation.", Journal of the American Chemical SocietyAugust,, 2017, 139(33), 11622-11628 [doi] [abs].

  33. Colell, JFP; Emondts, M; Logan, AWJ; Shen, K; Bae, J; Shchepin, RV; Ortiz, GX; Spannring, P; Wang, Q; Malcolmson, SJ; Chekmenev, EY; Feiters, MC; Rutjes, FPJT; Blümich, B; Theis, T; Warren, WS, "Direct Hyperpolarization of Nitrogen-15 in Aqueous Media with Parahydrogen in Reversible Exchange.", Journal of the American Chemical SocietyJune,, 2017, 139(23), 7761-7767 [doi] [abs].

  34. Ortiz, GX; Hemric, BN; Wang, Q, "Direct and Selective 3-Amidation of Indoles Using Electrophilic N-[(Benzenesulfonyl)oxy]amides.", Organic lettersMarch,, 2017, 19(6), 1314-1317 [doi] [abs].

  35. Colell, JFP; Logan, AWJ; Zhou, Z; Shchepin, RV; Barskiy, DA; Ortiz, GX; Wang, Q; Malcolmson, SJ; Chekmenev, EY; Warren, WS; Theis, T, "Generalizing, Extending, and Maximizing Nitrogen-15 Hyperpolarization Induced by Parahydrogen in Reversible Exchange.", The journal of physical chemistry. C, Nanomaterials and interfacesMarch,, 2017, 121(12), 6626-6634 [doi] [abs].

  36. Hendrick, CE; Wang, Q, "Emerging Developments Using Nitrogen-Heteroatom Bonds as Amination Reagents in the Synthesis of Aminoarenes.", The Journal of organic chemistryJanuary,, 2017, 82(2), 839-847 [doi] [abs].

  37. Liu, C; Wang, Q, "Arylation, Vinylation, and Alkynylation of Electron-Deficient (Hetero)arenes Using Iodonium Salts.", Organic lettersOctober,, 2016, 18(19), 5118-5121 [doi] [abs].

  38. Hemric, BN; Shen, K; Wang, Q, "Copper-Catalyzed Amino Lactonization and Amino Oxygenation of Alkenes Using O-Benzoylhydroxylamines.", Journal of the American Chemical SocietyMay,, 2016, 138(18), 5813-5816 [doi] [abs].

  39. Theis, T; Ortiz, GX; Logan, AWJ; Claytor, KE; Feng, Y; Huhn, WP; Blum, V; Malcolmson, SJ; Chekmenev, EY; Wang, Q; Warren, WS, "Direct and cost-efficient hyperpolarization of long-lived nuclear spin states on universal 15N2-diazirine molecular tags", Science AdvancesMarch,, 2016, 2(3), e1501438 [doi] [abs].

  40. Shen, K; Wang, Q, "Copper-catalyzed aminotrifluoromethylation of alkenes: A facile synthesis of CF3-containing lactams", Organic Chemistry FrontiersFebruary,, 2016, 3(2), 222-226, Royal Society of Chemistry (RSC) [doi] [abs].

  41. Hemric, BN; Wang, Q, "Copper-catalyzed intermolecular oxyamination of olefins using carboxylic acids and O-benzoylhydroxylamines.", Beilstein journal of organic chemistryJanuary,, 2016, 12, 22-28 [doi] [abs].

  42. Chen, Z; Wang, Q, "Synthesis of o-Aminophenols via a Formal Insertion Reaction of Arynes into Hydroxyindolinones.", Organic lettersDecember,, 2015, 17(24), 6130-6133 [doi] [abs].

  43. Shen, K; Wang, Q, "Copper-catalyzed diamination of unactivated alkenes with hydroxylamines.", Chemical scienceJuly,, 2015, 6(7), 4279-4283 [doi] [abs].

  44. McDonald, SL; Hendrick, CE; Bitting, KJ; Wang, Q, "Copper-Catalyzed Electrophilic Amination of Heteroaromatic and Aromatic C-H Bonds via TMPZnCl•LiCl Mediated Metalation.", Organic syntheses; an annual publication of satisfactory methods for the preparation of organic chemicalsJanuary,, 2015, 92, 356-372 [doi].

  45. Hendrick, CE; Wang, Q, "Synthesis of ortho-haloaminoarenes by aryne insertion of nitrogen-halide bonds.", The Journal of organic chemistryJanuary,, 2015, 80(2), 1059-1069 [doi] [abs].

  46. McDonald, SL; Wang, Q, "α-Amination of Phosphonates: A Direct Synthesis of α-Amino Phosphonic Acids and Their Derivatives", SynlettJuly,, 2014, 25(16), 2233-2238, Georg Thieme Verlag KG [doi] [abs].

  47. Feng, Y-X; Sokol, ES; Del Vecchio, CA; Sanduja, S; Claessen, JHL; Proia, TA; Jin, DX; Reinhardt, F; Ploegh, HL; Wang, Q; Gupta, PB, "Epithelial-to-mesenchymal transition activates PERK-eIF2α and sensitizes cells to endoplasmic reticulum stress.", Cancer discoveryJune,, 2014, 4(6), 702-715 [doi] [abs].

  48. McDonald, SL; Hendrick, CE; Wang, Q, "Copper-catalyzed electrophilic amination of heteroarenes and arenes by C-H zincation.", Angewandte Chemie (International ed. in English)April,, 2014, 53(18), 4667-4670 [doi] [abs].

  49. Wang, B; Rao, Y-H; Inoue, M; Hao, R; Lai, C-H; Chen, D; McDonald, SL; Choi, M-C; Wang, Q; Shinohara, ML; Yao, T-P, "Microtubule acetylation amplifies p38 kinase signalling and anti-inflammatory IL-10 production.", Nat CommunMarch,, 2014, 5, 3479 [doi] [abs].

  50. McDonald, SL; Wang, Q, "Selective α-amination and α-acylation of esters and amides via dual reactivity of O-acylhydroxylamines toward zinc enolates.", Chemical communications (Cambridge, England)March,, 2014, 50(19), 2535-2538 [doi] [abs].

  51. McDonald, SL; Wang, Q, "Copper-catalyzed α-amination of phosphonates and phosphine oxides: a direct approach to α-amino phosphonic acids and derivatives.", Angewandte Chemie (International ed. in English)February,, 2014, 53(7), 1867-1871 [doi] [abs].

  52. Ortiz, GX; Kang, B; Wang, Q, "One-pot synthesis of 3-azido- and 3-aminopiperidines by intramolecular cyclization of unsaturated amines.", The Journal of organic chemistryJanuary,, 2014, 79(2), 571-581 [24359462], [doi] [abs].

  53. Feng, Y; Theis, T; Liang, X; Wang, Q; Zhou, P; Warren, WS, "Storage of hydrogen spin polarization in long-lived 13C2 singlet order and implications for hyperpolarized magnetic resonance imaging.", J Am Chem SocJuly,, 2013, 135(26), 9632-9635 [23781874], [doi] [abs].

  54. Hendrick, CE; McDonald, SL; Wang, Q, "Insertion of arynes into N-halo bonds: a direct approach to o-haloaminoarenes.", Organic lettersJuly,, 2013, 15(13), 3444-3447 [23796022], [doi] [abs].

  55. Yuan, Y; Tang, AJ; Castoreno, AB; Kuo, S-Y; Wang, Q; Kuballa, P; Xavier, R; Shamji, AF; Schreiber, SL; Wagner, BK, "Gossypol and an HMT G9a inhibitor act in synergy to induce cell death in pancreatic cancer cells.", Cell death & diseaseJune,, 2013, 4(6), e690 [doi] [abs].

  56. Huang, H-T; Lacy, TC; Błachut, B; Ortiz, GX; Wang, Q, "An efficient synthesis of fluorinated azaheterocycles by aminocyclization of alkenes.", Organic lettersApril,, 2013, 15(8), 1818-1821 [23544433], [doi] [abs].

  57. Yuan, Y; Wang, Q; Paulk, J; Kubicek, S; Kemp, MM; Adams, DJ; Shamji, AF; Wagner, BK; Schreiber, SL, "A small-molecule probe of the histone methyltransferase G9a induces cellular senescence in pancreatic adenocarcinoma.", ACS chemical biologyJuly,, 2012, 7(7), 1152-1157 [doi] [abs].

  58. Kemp, MM; Wang, Q; Fuller, JH; West, N; Martinez, NM; Morse, EM; Weïwer, M; Schreiber, SL; Bradner, JE; Koehler, AN, "A novel HDAC inhibitor with a hydroxy-pyrimidine scaffold.", Bioorganic & medicinal chemistry lettersJuly,, 2011, 21(14), 4164-4169 [doi] [abs].

  59. Wang, Q; Schreiber, SL, "Copper-mediated amidation of heterocyclic and aromatic C-H bonds.", Organic lettersNovember,, 2009, 11(22), 5178-5180 [doi] [abs].

  60. Sun, C; Wang, Q; Brubaker, JD; Wright, PM; Lerner, CD; Noson, K; Charest, M; Siegel, DR; Wang, YM; Myers, AG, "“A robust platform for the synthesis of new tetracycline antibiotics", J. Am. Chem. Soc, 2008, 130(130), 17913 [doi] [abs].

  61. Padwa, A; Wang, Q, "Synthesis of the tetracyclic framework of the erythrina alkaloids using a [4 + 2]-cycloaddition/Rh(I)-catalyzed cascade of 2-imidofurans.", The Journal of organic chemistrySeptember,, 2006, 71(19), 7391-7402 [doi] [abs].

  62. Padwa, A; Wang, Q, "Rhodium(I)-catalyzed nucleophilic ring-opening reactions of oxabicyclo adducts derived from the [4 + 2]-cycloaddition of 2-imido-substituted furans.", The Journal of organic chemistryApril,, 2006, 71(8), 3210-3220 [doi] [abs].

  63. Wang, Q; Padwa, A, "Synthesis of the erythrina alkaloid 3-demethoxyerythratidinone. Novel acid-induced rearrangements of its precursors.", Organic lettersFebruary,, 2006, 8(4), 601-604 [doi] [abs].

  64. Padwa, A; Nara, S; Wang, Q, "Additive Pummerer reaction of heteroaromatic sulfilimines with carbon nucleophiles", Tetrahedron LettersJanuary,, 2006, 47(4), 595-597, Elsevier BV [doi] [abs].

  65. Padwa, A; Nara, S; Wang, Q, "Dichloroketene-induced cyclizations of vinyl sulfilimines: application of the method in the synthesis of (+/-)-desoxyeseroline.", The Journal of organic chemistryOctober,, 2005, 70(21), 8538-8549 [doi] [abs].

  66. Wang, Q; Nara, S; Padwa, A, "A new synthesis of gamma-lactams based on the reaction of vinyl sulfilimines with dichloroketene.", Organic lettersMarch,, 2005, 7(5), 839-841 [doi] [abs].

  67. Wang, Q; Padwa, A, "Rh(I)-catalyzed ring opening of an IMDAF-derived oxabicyclo cycloadduct as the key step in the synthesis of (+/-)-epi-zephyranthine.", Organic lettersJune,, 2004, 6(13), 2189-2192 [doi] [abs].

  68. Padwa, A; Brodney, MA; Lynch, SM; Rashatasakhon, P; Wang, Q; Zhang, H, "A new strategy toward indole alkaloids involving an intramolecular cycloaddition/rearrangement cascade.", The Journal of organic chemistryMay,, 2004, 69(11), 3735-3745 [doi] [abs].

  69. Padwa, A; Heidelbaugh, TM; Kuethe, JT; McClure, MS; Wang, Q, "Tandem Pummerer/Mannich Cyclization Cascade of α‐Sulfinylamides as a Method to Prepare Aza‐Heterocycles.", ChemInformJanuary,, 2003, 34(4), Wiley [doi] [abs].

  70. Padwa, A; Heidelbaugh, TM; Kuethe, JT; McClure, MS; Wang, Q, "Tandem Pummerer/Mannich cyclization cascade of alpha-sulfinylamides as a method to prepare aza-heterocycles.", The Journal of organic chemistryAugust,, 2002, 67(17), 5928-5937, WILEY [doi] [abs].

Chapter in Book

  1. Wang, Q, "Copper-Catalyzed Electrophilic Amination of sp2 and sp3 C-H Bonds Foreword", in COPPER-CATALYZED ELECTROPHILIC AMINATION OF SP2 AND SP3 C-H BONDS, 2016, V-VI.

  2. Wang, Q; Nicholas, H; Du, L, "DOS-Derived Small-Molecule Probes in Chemical Biology", in Diversity-Oriented Synthesis: Basics and Applications in Organic Synthesis, Drug Discovery, and Chemical Biology, edited by Trabocchi, A November,, 2015, 575-617, JOHN WILEY & SONS INC [doi].

  3. Hill, N.; Du, L.; Wang, Q., "DOS-Derived Small-Molecule Probes in Chemical Biology", in Diversity-Oriented Synthesis: Basics and Applications in Organic Synthesis, Drug Discovery, and Chemical Biology, edited by Trabocchi, A. , 2013, Wiley-VCH.